Postdoctoral Research Scientist in Covalent Drug Development for Emerging Cancer Targets Leiden University in Netherlands

Leiden University / Leiden University Medical Center / Leiden Early Drug Discovery and Development (LED3) are advertising a postdoctoral position in medicinal chemistry and chemical biology focused on a synthetic lethality target . The project is described as an exciting collaboration with Sylvie Noordermeer at Leiden University Medical Center, who pioneered the discovery of the synthetic lethal nature of the target. The lab environment is presented as highly collaborative and discovery-oriented...

Utrecht University is advertising a postdoc position in medicinal chemistry within the Chemical Biology and Drug Discovery division of the Utrecht Institute for Pharmaceutical Sciences (UIPS), in collaboration with researchers at UMC Utrecht . The project focuses on the discovery and optimization of novel Piezo1 inhibitors for sickle cell disease , combining virtual screening , AI techniques , computational drug discovery , organic synthesis , and chemical biology . The successful candidate will...

This post-doctoral fellowship at Lund University sits at the interface of organic chemistry and chemical biology . The project develops a modular chemical platform for targeted protein degradation in bacteria, using BacPROTACs as a new strategy to address antimicrobial resistance . The research centres on designing and synthesising bifunctional molecules that can recruit endogenous bacterial proteolytic machinery, including the ClpC:ClpP system, to selectively degrade essential proteins in drug-...

CNRS Research Director Anton Granzhan is recruiting for an 18-month postdoctoral position in bioorganic chemistry and chemical biology at LCBPT (CNRS – Université Paris Cité, Paris, France). The project builds on a recent discovery of small molecules that selectively bind DNA three-way junctions and show toxicity against certain cancer cells. The next stage is to design a new generation of macrocyclic TWJ ligands and heterobifunctional probes to investigate how these molecules act in cells. Suit...

Leiden University is recruiting a full-time postdoctoral candidate in medicinal chemistry and chemical biology to advance a drug discovery campaign against the synthetic lethality target EXO1. The project is a collaboration between the Pomplun Lab and Sylvie Noordermeer’s group at Leiden University Medical Center (LUMC), based in Leiden, Netherlands. The successful researcher will develop scaffold proposals for covalent and non-covalent inhibitors, optimize novel and existing compound series for...