Postdoctoral Researcher in Genome Stability and Aging (Garinis Lab, IMBB-FORTH, Greece) Foundation for Research and Technology-Hellas in Greece

The Foundation for Research and Technology-Hellas (FORTH), through its Institute of Molecular Biology and Biotechnology (IMBB), invites applications for a postdoctoral researcher position in the Genome (In)stability and Mammalian Physiology group, led by Prof. George Garinis. This opportunity is part of the Hevolution Foundation Geroscience Research Opportunities program, focusing on the project “Targeting genome stability as root cause of aging.”

The Garinis Lab investigates the impact of DNA damage on mammalian physiology during aging and its role in the premature onset of age-related diseases. The lab utilizes genetically engineered mouse models with defects in nucleotide excision repair and/or transcription, as well as mice expressing tagged DNA repair proteins. These models are combined with high-throughput, biochemical, molecular, and cellular biology methods to understand how mammalian cells counteract DNA damage-driven pathologies and prolong healthspan.

The current project aims to uncover the mechanisms of DNA repair gene regulation, particularly focusing on the DREAM complex as a master regulator of DNA repair capacities. The research will explore the evolutionary trade-offs of somatic DNA repair, the fitness costs of enhanced repair, and how DREAM inhibition may extend healthspan in mammals. The successful candidate will address these questions using advanced molecular and cellular biology techniques, mouse genetics, and bioimaging.

Applicants must have a BSc, MSc, and PhD in Biology, Medicine, Life Sciences, or related fields, with over 8 years of experience in DNA damage research in mammalian physiology and aging. A strong publication record (at least 5 papers in high-impact journals), certification in animal handling (e.g., FELASA), and fluency in English are required. Experience in nucleic acid processing, biochemical and molecular techniques, cell culture, and bioimaging is highly desirable. Participation in international scientific meetings and the ability to design, manage, and conduct research initiatives are considered assets.

The position offers a 3-month contract with the possibility of extension, and salary will be determined according to experience and Greek legislation. The anticipated start date is January 1, 2026. Applications should be submitted electronically by November 20, 2025, and must include the application form, CV, statement of purpose, contact details of two referees, and scanned copies of academic titles and qualifications. Shortlisted candidates will be invited for an interview, and the selection process will be based on a detailed evaluation of qualifications and experience.

For more information about the lab, visit https://www.garinislab.gr/. The official call and application details can be found at Euraxess and the IMBB website. For inquiries, contact [email protected].