Anna Katharina Herta Hirsch

Full professor (W3)

Saarland University

Germany

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Articles (20)

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity

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Year:

2024

Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy‐coupling factor transporters (ECFTs)

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Year:

2024

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

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Year:

2024

The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research

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Year:

2024

Correction: Fries et al. Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin A Using a Staphylococcus aureus Infection Model in Zebrafish Embryos. Int. J. Mol. Sci. 2023, 24, 12791

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Year:

2024

Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**

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Year:

2024

Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**

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Year:

2024

Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT

Article Link

Year:

2024

Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

Article Link

Year:

2024

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Article Link

Year:

2023

Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin A Using a Staphylococcus aureus Infection Model in Zebrafish Embryos

Article Link

Year:

2023

pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA

Article Link

Year:

2023

Disrupting Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor

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Year:

2023

Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in E. coli for Structure‐Based Drug Design

Article Link

Year:

2023

Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Article Link

Year:

2023

Not Every Hit‐Identification Technique Works on 1‐Deoxy‐ <scp>d</scp> ‐Xylulose 5‐Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign

Article Link

Year:

2023

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors

Article Link

Year:

2023

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle

Article Link

Year:

2023

Fighting antibiotic resistance—strategies and (pre)clinical developments to find new antibacterials

Article Link

Year:

2023

Selective Activation of a TRPC6 Ion Channel Over TRPC3 by Metalated Type-B Polycyclic Polyprenylated Acylphloroglucinols

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Year:

2023

Collaborators (14)

Rick Oerlemans

University of Groningen

NETHERLANDS

Martin Empting

GERMANY

Mostafa M. Hamed

Helmholtz Institute for Pharmaceutical Research Saarland

GERMANY

Matthew Groves

Assistant Professor

Rijksuniversiteit Groningen

NETHERLANDS

Bernd Plietker

GERMANY

Rolf Müller

GERMANY

Andrea Volkamer

Professor

Saarland University

GERMANY

Jesko Koehnke

University of Glasgow

UNITED KINGDOM

Anton Bleisch

Technische Universität Dresden

GERMANY

Claus-Michael Lehr

Professor and Head of Dept.

Helmholtz Institute for Pharmaceutical Research Saarland

GERMANY

Joy Birkelbach

Helmholtz Institute for Pharmaceutical Research Saarland

GERMANY

Sven Marcel Stefan

University Professor

Medical University of Lublin

POLAND

Agnes-Valencia Weiss

Saarland University

GERMANY

Jennifer Herrmann

Helmholtz Institute for Pharmaceutical Research Saarland

GERMANY

Anna Katharina Herta Hirsch

Research Interests

Explore related searches

Contact this professor

Articles (20)

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity

Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy‐coupling factor transporters (ECFTs)

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research

Correction: Fries et al. Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin A Using a Staphylococcus aureus Infection Model in Zebrafish Embryos. Int. J. Mol. Sci. 2023, 24, 12791

Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**

Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**

Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT

Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin A Using a Staphylococcus aureus Infection Model in Zebrafish Embryos

pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA

Disrupting Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor

Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in E. coli for Structure‐Based Drug Design

Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Not Every Hit‐Identification Technique Works on 1‐Deoxy‐ <scp>d</scp> ‐Xylulose 5‐Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle

Fighting antibiotic resistance—strategies and (pre)clinical developments to find new antibacterials

Selective Activation of a TRPC6 Ion Channel Over TRPC3 by Metalated Type-B Polycyclic Polyprenylated Acylphloroglucinols

Collaborators (14)

Rick Oerlemans

Martin Empting

Mostafa M. Hamed

Matthew Groves

Bernd Plietker

Rolf Müller

Andrea Volkamer

Jesko Koehnke

Anton Bleisch

Claus-Michael Lehr

Joy Birkelbach

Sven Marcel Stefan

Agnes-Valencia Weiss

Jennifer Herrmann

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