Alicia Lundby
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Alicia Lundby is a Professor at the University of Copenhagen in Denmark. Her research focuses on integrating -omic technologies to investigate cardiac disease, utilizing multi-omics strategies to understand heart rhythm, and studying molecular mechanisms related to oncogenic mutations. Recent publications highlight her work on quantitative proteomics and the remodeling of protein landscapes in cardiac specimens.
Positions (4)
Alicia Lundby
University of Copenhagen
NaN years ago
No summary provided for this position.
NaN years ago
Alicia Lundby
University of Copenhagen
9 months ago
The Cardiac Proteomics & Systems Biology Group at the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, is seeking a highly motivated PhD fellow. The successful candidate will join a dynamic research team led by Professor Alicia Lundby, focusing on advancing spatial proteomics of the heart and elucidating the molecular architecture of the cardiac conduction system (CCS). This research aims to uncover mechanisms underlying heart rate control and arrhythmogenic disease, using cutting-edge methodologies such as laser capture microdissection and quantitative mass spectrometry-based proteomics. The project, supported by a grant from the Independent Research Fund Denmark, will generate cell type-resolved proteomes of CCS regions, with a particular focus on the sinus node in both animal models and human tissue. The fellow will develop and optimize spatial proteomics workflows, perform quantitative proteomics and data analysis, and collaborate on multi-omics investigations of cardiac disease mechanisms. The research environment offers access to state-of-the-art laboratories, core facilities, and modern office spaces, fostering academic excellence, creativity, and responsibility. Applicants should hold an M.Sc. degree in Biotechnology, Biochemistry, Biomedical Sciences, or a related field, with a strong academic record and research experience. Hands-on expertise in mass spectrometry-based proteomics, data processing, laser capture microdissection, image-guided tissue analysis, fluorescent microscopy, and knowledge of cardiac physiology are highly desirable. Strong English communication skills and the ability to work both independently and collaboratively are essential. The master's degree must be equivalent to a Danish master's degree, and applicants may need to provide an official assessment of their education. The position is fully funded, with a starting monthly salary of approximately 31,200 DKK (about 4,170 EUR) plus pension, for a period of 3 years. The workplace is located at Maersk Tower, The Panum Institute, University of Copenhagen, Denmark. The suggested start date is between March and September 2026. The application deadline is 8 January 2026. To apply, submit your application online via the University of Copenhagen job portal, including a cover letter, CV, relevant diplomas, transcripts, list of publications, and contact details for two referees. For more information, visit the Cardiac Proteomics Group website at www.lundbylab.com or contact Professor Alicia Lundby at [email protected].
9 months ago
Alicia Lundby
University of Copenhagen
9 months ago
The Cardiac Proteomics & Systems Biology Group at the Department of Biomedical Sciences, University of Copenhagen, invites applications for a fully funded PhD fellowship in spatial proteomics of cardiac conduction and disease mechanisms. This opportunity is part of a newly awarded project grant from the Independent Research Fund Denmark, focusing on the project “Deconvolution of the Heartbeat: Spatially Resolved Profiling of Cells and Proteins of the Human Conduction System.” The research aims to develop and apply advanced methodologies to map the cellular and molecular architecture of the human cardiac conduction system (CCS), which is crucial for coordinated heartbeats and heart rate control. Disruption of CCS components can lead to impaired cardiac function and life-threatening arrhythmias. The project will generate cell type-resolved proteomes of CCS regions, focusing on the sinus node in both animal models and human tissue. Using laser capture microdissection and quantitative mass spectrometry-based proteomics, the PhD fellow will investigate protein remodeling at cellular resolution and gain insights into the biological mechanisms underlying CCS function and arrhythmogenic disease. Key responsibilities include developing and optimizing spatial proteomics workflows for cardiac tissue, performing quantitative proteomics and data analysis, collaborating on multi-omics investigations of cardiac disease mechanisms, and communicating findings through publications and presentations. The successful candidate will join the Lundby Group, a dynamic, interdisciplinary research environment dedicated to advancing molecular insights into cardiac pathophysiology, with access to state-of-the-art laboratories and core facilities. Applicants must have an M.Sc. degree in Biotechnology, Biochemistry, Biomedical Sciences, or a related field, with a strong academic track record and research experience. Hands-on expertise in mass spectrometry-based proteomics, proteomics data processing, laser capture microdissection, fluorescent microscopy, or cellular and molecular cardiac physiology is required. Strong English communication skills and the ability to work both independently and collaboratively are essential. The master's degree must be equivalent to a Danish master's degree, and applicants may need to provide an official assessment of their education. The position is fully funded, offering a monthly salary starting at approximately 31,200 DKK (about 4,170 EUR) plus pension, for a period of 3 years. The workplace is located at Maersk Tower, The Panum Institute, University of Copenhagen, Denmark. The application deadline is January 8, 2026, and the suggested start date is between March and September 2026. To apply, submit an online application via the University of Copenhagen job portal, including a cover letter, CV, relevant diplomas (with English translation if needed), a certified copy of your master's diploma or recent transcript, a list of publications, and contact details for two referees. For more information, contact Professor Alicia Lundby at [email protected] or visit the Cardiac Proteomics Group website at www.lundbylab.com.
9 months ago
Alicia Lundby
University of Copenhagen
9 months ago
The University of Copenhagen is inviting applications for a PhD Fellow in Spatial Proteomics of Cardiac Conduction and Disease Mechanisms. This opportunity is based in the Cardiac Proteomics & Systems Biology Group, led by Professor Alicia Lundby, at the Department of Biomedical Sciences. The research focuses on mapping the heart’s conduction system at cellular resolution using advanced spatial proteomics techniques, including laser-capture microdissection and quantitative LC-MS/MS. The project aims to uncover the molecular architecture of the cardiac conduction system (CCS) and elucidate mechanisms underlying heart rate control and arrhythmogenic disease. The successful candidate will develop and optimize spatial proteomics workflows for cardiac tissue, perform quantitative proteomics and data analysis, and collaborate on multi-omics investigations of cardiac disease mechanisms. The position offers comprehensive training in proteomics, multi-omics integration, and large-scale data analysis, with access to state-of-the-art laboratories and core facilities at the Maersk Tower, University of Copenhagen. Applicants should hold an M.Sc. degree in Biotechnology, Biochemistry, Biomedical Sciences, or a related field, with a strong academic record and research experience. Hands-on expertise in mass spectrometry-based proteomics, proteomics data processing, laser capture microdissection, image-guided tissue analysis, fluorescent microscopy, or cardiac physiology is highly desirable. Strong English communication skills and the ability to work both independently and collaboratively are essential. The master's degree must be equivalent to a Danish master's degree, and applicants may be required to provide an official assessment of their degree. The PhD position is fully funded, with a starting salary of approximately 31,200 DKK/month plus pension, in accordance with Danish state agreements. Employment is full-time for three years. The application deadline is 8 January 2026, and the suggested start date is between March and September 2026. To apply, candidates must submit an online application via the University of Copenhagen job portal, including a cover letter, CV, relevant diplomas (with English translation if necessary), transcript of records, list of publications, and contact details for two referees. For further information, applicants may contact Professor Alicia Lundby at [email protected] or visit the group’s website at www.lundbylab.com . This position is ideal for candidates interested in spatial proteomics, cardiac biology, systems biology, and advanced biomedical research. The University of Copenhagen offers a dynamic, interdisciplinary research environment dedicated to academic excellence and innovation in the life sciences.
9 months ago
Articles (6)
Year:
2025
Year:
2025
Aims In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood. Using proteomics, this study aimed to dissect the protein and phosphorylation remodelling within the sinus node in an animal model of HF with concurrent SND. Methods and results We acquired deep sinus node proteomes and phosphoproteomes in mice with heart failure and SND and report extensive remodelling. Intersecting the measured (phospho)proteome changes with human genomics pharmacovigilance data, highlighted downregulated proteins involved in electrical activity such as the pacemaker ion channel, Hcn4. We confirmed the importance of ion channel downregulation for sinus node physiology using computer modelling. Guided by the proteomics data, we hypothesized that an inflammatory response may drive the electrophysiological remodeling underlying SND in heart failure. In support of this, experimentally induced inflammation downregulated Hcn4 and slowed pacemaking in the isolated sinus node. From the proteomics data we identified proinflammatory cytokine-like protein galectin-3 as a potential target to mitigate the effect. Indeed, in vivo suppression of galectin-3 in the animal model of heart failure prevented SND. Conclusion Collectively, we outline the protein and phosphorylation remodeling of SND in heart failure, we highlight a role for inflammation in electrophysiological remodelling of the sinus node, and we present galectin-3 signalling as a target to ameliorate SND in heart failure.
Year:
2024
Year:
2024
Year:
2020
Year:
2020
Collaborators (6)
Konstantin Kahnert
Stanford University
Kristine Boisen Olsen
Københavns Universitet
Thomas Hartvig Lindkær Jensen
Københavns Universitet
Sami Al-Othman
University of Manchester
Luca Soattin
Københavns Universitet
Kristina Bennet Emdal
Københavns Universitet
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