Andreas Hougaard Laustsen

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Technical University of Denmark

Denmark

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Professors in Immunology

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Recombinant snakebite antivenom for sub-Saharan Africa

Open Date: 2021-01-01

Close Date: 2025-12-31

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Collaborators (35)

Chiara Francavilla

The University of Manchester

UNITED KINGDOM

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Tulika Tulika

Technical University of Denmark

DENMARK

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Bjørn Gunnar Voldborg

Technical University of Denmark

DENMARK

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Anne Ljungars

Technical University of Denmark

DENMARK

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Nick Jean Burlet

Technical University of Denmark

DENMARK

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Susanne Brix Pedersen

Technical University of Denmark

DENMARK

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Timothy P. Jenkins

Technical University of Denmark

DENMARK

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Julian Harrison

ETH Zürich

SWITZERLAND

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Erwin Marten Schoof

Technical University of Denmark

DENMARK

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Stephen Mackessy

Professor of Biology

University of Northern Colorado

UNITED STATES

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Melisa Benard Valle

Technical University of Denmark

DENMARK

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Line Ledsgaard

Technical University of Denmark

DENMARK

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Rachel Clare

Academic, Senior Lecturer in Biochemistry

Edge Hill University

UNITED KINGDOM

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Selma Belfakir

Technical University of Denmark

DENMARK

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Nicholas Casewell

Professor of Tropical Disease Biology

Liverpool School of Tropical Medicine

UNITED KINGDOM

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Konstantinos Kalogeropoulos

Technical University of Denmark

DENMARK

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Esperanza Rivera-de-Torre

Technical University of Denmark

DENMARK

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Victor Greiff

Professor

University of Oslo

NORWAY

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Jonas Arnold Jürgensen

Technical University of Denmark

DENMARK

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Christoffer Vinther Sørensen

Technical University of Denmark

DENMARK

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Serge Muyldermans

Professor

Vrije Universiteit Brussel

BELGIUM

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Sara Petersen Bjørn

Technical University of Denmark

DENMARK

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Lone Gram

Technical University of Denmark

DENMARK

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Jens Preben Morth

Technical University of Denmark

DENMARK

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Marcus Petersson

Technical University of Denmark

DENMARK

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Jan Terje Andersen

University of Oslo

NORWAY

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Anna Christina Adams

Group head pharmaceutical biotechnology

RWTH Aachen University

GERMANY

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Lars Ellgaard

Professor

University of Copenhagen

DENMARK

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Tina Dalgaard

Associate Professor

Aarhus University

DENMARK

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Winnie Edith Svendsen

Technical University of Denmark

DENMARK

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Lise Marie Grav

Technical University of Denmark

DENMARK

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Aleksander Haack

Technical University of Denmark

DENMARK

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Shirin Ahmadi

Technical University of Denmark

DENMARK

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Markus-Frederik Bohn

Associate Professor

Danmarks Tekniske Universitet

DENMARK

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Georgina Ross

Chief Technology Officer

DENMARK

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Andreas Hougaard Laustsen

Research Interests

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Contact this professor

Recent Grants

Articles (30)

Discovery of broadly neutralizing V H Hs against short-chain α-neurotoxins using a consensus toxin as an antigen

De novo designed proteins neutralize lethal snake venom toxins

InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments

Target product profiles for pan-Africa recombinant antivenoms against neurotoxic or hemotoxic and cytotoxic snakebite envenoming

Leveraging cellulose-binding domains to orient and immobilize single-domain antibodies onto paper-based immunoassays

In-feed provision of binding proteins sustains piglet gut health and mitigates ETEC-induced post-weaning diarrhea

Orally delivered toxin–binding protein protects against diarrhoea in a murine cholera model

Comment on: What is new in the treatment of snakebite envenoming? Opportunities and challenges

Post-assembly Plasmid Amplification for Increased Transformation Yields in E. coli and S. cerevisiae

Progress and Challenges in the Field of Snakebite Envenoming Therapeutics

ExpoSeq: simplified analysis of high-throughput sequencing data from antibody discovery campaigns

Discovery of broadly‐neutralizing antibodies against brown recluse spider and Gadim scorpion sphingomyelinases using consensus toxins as antigens

A comparative study of the performance of E. coli and K. phaffii for expressing α-cobratoxin

Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling

Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper

Cellulose immobilization strategies for paper-based immunoassays

Fit‐for‐purpose heterodivalent single‐domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile

Recombinant snake antivenoms get closer to the clinic

A comparative study of protein structure prediction tools for challenging targets

In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

Assessing developability early in the discovery process for novel biologics

Characterisation of two snake toxin-targeting human monoclonal immunoglobulin G antibodies expressed in tobacco plants

Neutralization capacity of recombinant antivenoms based on monoclonal antibodies and nanobodies

Cross-reactivity trends when selecting scFv antibodies against snake toxins using a phage display-based cross-panning strategy

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

Prototyping of a lateral flow assay based on monoclonal antibodies for detection of Bothrops venoms

Orally delivered single-domain antibodies against gastrointestinal pathogens

A single-chain variable fragment selected against a conformational epitope of a recombinantly produced snake toxin using phage display

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules

In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom

Collaborators (35)

Chiara Francavilla

Tulika Tulika

Bjørn Gunnar Voldborg

Anne Ljungars

Nick Jean Burlet

Susanne Brix Pedersen

Timothy P. Jenkins

Julian Harrison

Erwin Marten Schoof

Stephen Mackessy

Melisa Benard Valle

Line Ledsgaard

Rachel Clare

Selma Belfakir

Nicholas Casewell

Konstantinos Kalogeropoulos

Esperanza Rivera-de-Torre

Victor Greiff

Jonas Arnold Jürgensen

Christoffer Vinther Sørensen

Serge Muyldermans

Sara Petersen Bjørn

Lone Gram

Jens Preben Morth

Marcus Petersson

Jan Terje Andersen

Anna Christina Adams

Lars Ellgaard

Tina Dalgaard

Winnie Edith Svendsen

Lise Marie Grav

Aleksander Haack

Shirin Ahmadi

Markus-Frederik Bohn

Georgina Ross

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