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Anilkumar Gopalakrishnapillai

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Head, Cancer Stem Cell Laboratory

Nemours Childrens Hospital

United States

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About

Dr. Anilkumar Gopalakrishnapillai is the Head of the Cancer Stem Cell Laboratory at Nemours Children’s Hospital, USA. His research focuses on leukemia, cancer stem cells, and the bone marrow microenvironment, with significant contributions to understanding Down syndrome-related leukemia and targeted immunotherapy. His recent publications explore innovative treatment options and molecular dependencies in pediatric hematological malignancies.

Recent Grants

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Generation of Down Syndrome Myeloid Leukemia Model using induced pluripotent stem cells and Crispr/cas9 technologies

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Imtelestat regulates pediatric acute myeloid leumic stem cell growth

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DLK1 is a novel target for Myeloid Leukemia associated with Down syndrome

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Articles (15)

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2026

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2026

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2025

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2023

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2023

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (7)

Baskar Ramdas

Associate Research Professor

University of Indianapolis

UNITED STATES

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Dirk Heckl

Professor (W3) and Director

Goethe University Frankfurt

GERMANY

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Reuben Kapur

Professor

Indiana University School of Medicine

UNITED STATES

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Sonali Barwe

Senior Research Scientist; Head, Cancer Modeling Laboratory; Director, Cell Science Core; Co-Director Nemours Summer Undergraduate Research Program; Radiation Safety Officer for Research Delaware Valley; Nemours contact for INBRE Summer Scholars

Nemours Children's Hospital Delaware

UNITED STATES

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Sophie Paczesny

Department Chair

Medical University of South Carolina

UNITED STATES

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Santhosh Kumar

Assistant Research Professor

Indiana State University

UNITED STATES

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Maegan Capitano

Assistant Professor

Indiana University School of Medicine

UNITED STATES

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Anilkumar Gopalakrishnapillai

Research Interests

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About

Recent Grants

Articles (15)

DLK1 is a GATA1s-driven dependency and therapeutic target in Down syndrome–associated myeloid leukemia

Mesothelin promotes acute myeloid leukemia progression through LYN-dependent signaling

T cell-engaging bispecific antibodies for myeloid malignancies: Targets, formats, and clinical challenges

ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche

Dual targeting of tumoral cells and immune microenvironment by blocking the IL-33/IL1RL1 pathway

Bone Marrow Microenvironment-Induced Chemoprotection in <i>KMT2A</i> Rearranged Pediatric AML Is Overcome by Azacitidine–Panobinostat Combination

Down syndrome and leukemia: An insight into the disease biology and current treatment options.

Tetraspanins set the stage for bone marrow microenvironment-induced chemoprotection in hematologic malignancies.

Imetelstat Induces Leukemia Stem Cell Death in Pediatric Acute Myeloid Leukemia Patient-Derived Xenografts

Mesothelin: An Immunotherapeutic Target beyond Solid Tumors

Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia

Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of <i>GATA1</i> and <i>STAG2</i> Mutations in Induced Pluripotent Stem Cells with Trisomy 21

Immunotherapeutic Targeting of Mesothelin Positive Pediatric AML Using Bispecific T Cell Engaging Antibodies

Harnessing the Power of Induced Pluripotent Stem Cells and Gene Editing Technology: Therapeutic Implications in Hematological Malignancies

The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML

Collaborators (7)

Baskar Ramdas

Dirk Heckl

Reuben Kapur

Sonali Barwe

Sophie Paczesny

Santhosh Kumar

Maegan Capitano

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