Anna Mascellani Bergo
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Articles (16)
Year:
2024
Five putrescine and spermidine derivatives (1–5) together with five rotenoids (6–10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 ± 1.9% for AChE and 90.0 ± 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
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2024
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2024
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2024
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2024
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2024
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2024
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2023
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2023
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2023
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2023
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2023
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2022
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2022
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2022
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2021
Collaborators (26)
Ondrej Cinek
Professor
Charles University
Jan Schwarz
Charles University, Faculty of Medicine in Pilsen
Filip Mercl
Czech University of Life Sciences Prague
Vit Neuman
-
Svatopluk Henke
Assistant Professor
University of Chemistry and Technology
Pavel Tlustos
Prof.
Czech University of Life Sciences Prague
Tersia Needham
Associate Professor
Czech University of Life Sciences Prague
Antonella Castagna
associate professor
University of Pisa
Jaroslav Havlik
Czech University of Life Sciences Prague
Pavel Kloucek
Czech University of Life Sciences Prague
Richard Hansen
Clinical Reader in Child Health
University of Dundee
Kateřina Valentová
Head of the Laboratory
Institute of Microbiology
Johana Rondevaldova
Czech University of Life Sciences Prague
GIACOMO PALAI
University of Pisa
Matěj Božik
Czech University of Life Sciences Prague
Giovanni Caruso
University of Pisa
Pavel Novy
Czech University of Life Sciences Prague
Milan Malaník
Masaryk University
Jakub Treml
Masaryk University
Jakub Hurych
Charles University
Rudolf Horváth
Department head
University Hospital in Motol
Ladislav Kokoska
Full Professor
-
Petr Marsik
Czech University of Life Sciences Prague
S W F Milling
University of Glasgow
Konstantinos Gkikas
University of Glasgow
Martin Kamler
Institute for Bee Research
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