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Antonio Laghezza

Professore associato

University Name

Italy

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Research Interests

Pharmaceutical Chemistry

90%

Organic Chemistry

10%

Bioactive Compound

40%

Natural Product Synthesis

30%

Chemical Biology

30%

Endocannabinoid

30%

Terpenoid Chemistry

20%

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Articles13

Deep Eutectic Solvents (DESs) as Alternative Sustainable Media for the Extraction and Characterization of Bioactive Compounds from Winemaking Industry Wastes

Article Link

Year:

2025

AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis

Article Link

Year:

2024

Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates

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Year:

2024

Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase

Article Link

Year:

2023

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition

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Year:

2023

A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition

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Year:

2023

Het(aryl)isatin to het(aryl)aminoindoline scaffold hopping: A route to selective inhibitors of matrix metalloproteinases

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Year:

2022

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease

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Year:

2022

Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect

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Year:

2022

A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity

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Year:

2022

A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE)

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Year:

2022

Thiazolidinedione “Magic Bullets” Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects

Article Link

Year:

2021

(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone

Article Link

Year:

2021

Collaborators16

Vincenzo Tufarelli

Associate Professor in Animal Nutrition

University of Bari Aldo Moro

ITALY

Leonardo Pisani

ITALY

Angela STEFANACHI

University of Bari

ITALY

Sílvia Chaves

Professora Auxiliar

Universidade de Lisboa Instituto Superior Técnico

PORTUGAL

Fulvio Loiodice

ITALY

Benjamin Delprat

University of Montpellier

FRANCE

Stefania Villa

ITALY

Marialessandra Contino

University of Bari Aldo Moro

ITALY

Fiorella Meneghetti

University of Milan

ITALY

Antonio Lavecchia

University of Naples Federico II

ITALY

Alessia Carocci

ITALY

Mariangela Agamennone

Associate professor

University of Chieti-Pescara

ITALY

M. Amelia Santos

Professor

Universidade de Lisboa Instituto Superior Técnico

PORTUGAL

Luca Piemontese

University of Bari Aldo Moro

ITALY

Mauro Niso

Associate Professor

ITALY

Cosimo Altomare

University of Bari Aldo Moro

ITALY

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