Sílvia Chaves

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Professora Auxiliar

Universidade de Lisboa Instituto Superior Técnico

Portugal

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About

Dr. Sílvia Chaves is an Auxiliar Professor at the Universidade de Lisboa Instituto Superior Técnico in Portugal. Her research focuses on the development of new therapeutic agents for Alzheimer’s disease, emphasizing multi-target drug candidates and molecular modeling techniques. Recent publications include studies on Rivastigmine-based hybrids and innovative imaging probes for neurodegenerative conditions.

Recent Grants

Grant: Close

De pequenas moléculas bioactivas a uma abordagem ÓMICA integrada: Ferramentas de Espectrometria de Massa para a compreensão mecanística de propriedades farmacológicas e funcionais, toxicidade e respostas ao stress

Open Date: 2013-06-01

Close Date: 2016-12-01

Grant: Close

Novas matrizes sólidas quelantes com hidroxipirimidinonas imobilizadas para aplicações ambientais e biológicas

Open Date: 2008-12-01

Close Date: 2012-11-01

Grant: Close

Novo Tipo de Compostos Orientados para Receptores Biológicos com Potenciais Aplicações Farmacológicas

Open Date: 2006-10-01

Close Date: 2010-09-01

Grant: Close

Chemistry discovers the child

Open Date: 2006-01-01

Close Date: 2008-01-01

Grant: Close

Synthesis and metal binding ability of new chelating agents for potential medical application

Open Date: 2006-01-01

Close Date: 2007-01-01

Articles (16)

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2025

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2022

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2022

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2021

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2021

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2021

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2021

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2021

Collaborators (13)

Antonio Laghezza

Professore associato

ITALY

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M. EUGENIA DE LEON GONZALEZ

Profesor Titular Universidad

Universidad Complutense de Madrid

SPAIN

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Sandra M Cardoso

Assistant Professor

Universidade do Porto Faculdade de Medicina

PORTUGAL

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Rita C. Guedes

Universidade de Aveiro

PORTUGAL

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Péter Buglyó

University of Debrecen

HUNGARY

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David Vicente-Zurdo

Assistant Professor

Universidad CEU San Pablo

SPAIN

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Alessia Carocci

ITALY

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Lurdes Gano

Researcher

Universidade de Lisboa Instituto Superior Técnico

PORTUGAL

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M. Amelia Santos

Professor

Universidade de Lisboa Instituto Superior Técnico

PORTUGAL

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Luca Piemontese

University of Bari Aldo Moro

ITALY

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Éva Tóth

FRANCE

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Cosimo Altomare

University of Bari Aldo Moro

ITALY

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Katalin Várnagy

full professor

University of Debrecen

HUNGARY

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Sílvia Chaves

Research Interests

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About

Recent Grants

Articles (16)

Rivastigmine Templates with Antioxidant Motifs—A Medicinal Chemist’s Toolbox Towards New Multipotent AD Drugs

Gadolinium Complex with Tris-Hydroxypyridinone as an Input for New Imaging Probes: Thermodynamic Stability, Molecular Modeling and Biodistribution

Editorial on Special Issue “The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs”

New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease

Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates

Controlo de Biometais no Contexto de Fármacos Multifuncionais para a Doença de Alzheimer

Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease

Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms

GdIII and GaIII complexes with a new tris-3,4-HOPO ligand as new imaging probes: complex stability, magnetic properties and biodistribution

Multifunctional Small Molecules as Potential Anti-Alzheimer’s Disease Agents

Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity

Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimers Disease Agents

Multi-Targeting Tacrine Conjugates with Cholinesterase and Amyloid-Beta Inhibitory Activities: New Anti-Alzheimer's Agents

Collaborators (13)

Antonio Laghezza

M. EUGENIA DE LEON GONZALEZ

Sandra M Cardoso

Rita C. Guedes

Péter Buglyó

David Vicente-Zurdo

Alessia Carocci

Lurdes Gano

M. Amelia Santos

Luca Piemontese

Éva Tóth

Cosimo Altomare

Katalin Várnagy

Make your next move.

Sílvia Chaves

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (16)

Rivastigmine Templates with Antioxidant Motifs—A Medicinal Chemist’s Toolbox Towards New Multipotent AD Drugs

Gadolinium Complex with Tris-Hydroxypyridinone as an Input for New Imaging Probes: Thermodynamic Stability, Molecular Modeling and Biodistribution

Editorial on Special Issue “The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs”

New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease

Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates

Controlo de Biometais no Contexto de Fármacos Multifuncionais para a Doença de Alzheimer

Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease

Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms

GdIII and GaIII complexes with a new tris-3,4-HOPO ligand as new imaging probes: complex stability, magnetic properties and biodistribution

Multifunctional Small Molecules as Potential Anti-Alzheimer’s Disease Agents

Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity

Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimers Disease Agents

Multi-Targeting Tacrine Conjugates with Cholinesterase and Amyloid-Beta Inhibitory Activities: New Anti-Alzheimer's Agents

Collaborators (13)

Antonio Laghezza

M. EUGENIA DE LEON GONZALEZ

Sandra M Cardoso

Rita C. Guedes

Péter Buglyó

David Vicente-Zurdo

Alessia Carocci

Lurdes Gano

M. Amelia Santos

Luca Piemontese

Éva Tóth

Cosimo Altomare

Katalin Várnagy

Make your next move.

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimers Disease Agents