Ashley L St. John
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Articles (14)
Year:
2024
Year:
2024
Summary Mast cells (MCs) are multifunctional immune cells that express a diverse repertoire of surface receptors and pre-stored bioactive mediators. They are traditionally recognized for their involvement in allergic and inflammatory responses, yet there is a growing body of literature highlighting their contributions to mounting adaptive immune responses. In particular, there is growing evidence that MCs can serve as antigen-presenting cells, owing to their often close proximity to T cells in both lymphoid organs and peripheral tissues. Recent studies have provided compelling support for this concept, by demonstrating the presence of antigen processing and presentation machinery in MCs and their ability to engage in classical and non-classical pathways of antigen presentation. However, there remain discrepancies and unresolved questions regarding the extent of the MC’s capabilities with respect to antigen presentation. In this review, we discuss our current understanding of the antigen presentation by MCs and its influence on adaptive immunity.
Year:
2023
Year:
2023
Year:
2023
Year:
2023
Year:
2023
Year:
2022
Year:
2022
Year:
2022
Year:
2021
Year:
2021
Year:
2021
Year:
2021
Collaborators (50)
Dustin Duncan
Assistant Professor
Brock University
Lena Ho
Assistant Professor
Duke-NUS Medical School
Jadel M. Kratz
Head of Discovery and Partnerships LATAM
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Adam Claridge-Chang
Associate Professor
Duke-NUS Medical School
Iain Greig
University of Aberdeen
Davide Maria Ferraris
Associate Professor
Università degli Studi del Piemonte Orientale
Kavita Gadar
University of Birmingham
Nathan Merrill
University of Michigan
Teemu Haikarainen
Tampere University
Giulia Girolimetti
Università del Salento
Jiyoun Lee
Professor
Sungshin Women's University
Timothy O'Meara
Harvard University
Masfique Mehedi
Assistant Professor
North Dakota State University
GOKHAN CILDIR
University of South Australia
Brandon Pressly
Denali Therapeutics
Gracjan Michlewski
Professor
International Institute of Molecular and Cell Biology
Ashleigh Paparella
Lecturer
University of Sydney
Sylvie Alonso
National University of Singapore (NUS)
Alice Vrielink
University of Western Australia
Kayode Ojo
University of Washington
Evripidis Gavathiotis
Professor
Albert Einstein College of Medicine
Van Hung Vuong Le
Københavns Universitet
Juan José Lasarte
Universidad de Navarra
Alexander Agoulnik
Florida International University
Angelo Taglialatela
Columbia University Irving Medical Center
William Kerr
Professor of Microbiology & Immunology
SUNY Upstate Medical University
Isin Cakir
Assistant Professor of Medicine
University of Pittsburgh
Agnidipta Ghosh
Albert Einstein College of Medicine
Manjunatha Kini
Professor
National University of Singapore (NUS)
Christian Weber
Chair in Vascular Medicine and Physician-in-Chief
LMU Klinikum
William Bradshaw
University of Oxford
Deirdre Coombe
Professor
Curtin University
Van Chi Thai
University of Western Australia
Andrea Ilari
Istituto di Biologia e Patologia Molecolari Consiglio Nazionale delle Ricerche
David Siderovski
Professor and Chairman
University of North Texas Health Science Center
Jonathan So
Assistant Professor
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
Kirsikka Musta
Tampere University
Charlene M. Kahler
University of Western Australia
Silvia Buroni
Associate Professor
Università degli Studi di Pavia
Megan O'Mara
Professor
University of Queensland
Maximilien Evrard
University of Melbourne
Rajkumar Verma
Assistant Professor
University of Connecticut School of Medicine
Owen Rackham
University of Southampton
Robert Bradley
Full Professor
Fred Hutchinson Cancer Research Center
Yogesh Gupta
Associate Professor, with Tenure
University of Texas Health Science Center at San Antonio
Thomas Kampourakis
Lecturer
King’s College London
John Bruning
Senior Lecturer
University of Adelaide
William Brent Clayton
Associate Research Professor of Medicine
Indiana University School of Medicine
Jarrod Mousa
Assistant Professor
University of Georgia
Martin St. Maurice
Associate Professor
Marquette University
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