Thomas Kampourakis

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Lecturer

King’s College London

United Kingdom

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About

Dr. Thomas Kampourakis is a Lecturer at King's College London, UK. His research primarily focuses on cardiac muscle biology and utilizes advanced biophysical techniques, artificial intelligence, and biochemical assays to investigate cardiac myosin binding protein-C, protein kinase activity, and the structural dynamics of troponin. His recent publications explore various aspects of cardiac physiology, including hypertrophic cardiomyopathy and the development of novel fluorescent probes.

Recent Grants

Grant: Close

Length-dependent activation in human myocardium

Open Date: 2020-09-01

Close Date:

Grant: Close

Isothermal titration calorimetry instrumentation for structural biology, biological mechanisms and drug discovery

Open Date: 2020-04-01

Close Date: 2021-04-01

Grant: Close

Targeting the myofilaments to correct heart muscle dysfunction

Open Date: 2020-01-01

Close Date: 2023-01-01

Grant: Close

Cardiac thick filament modulators: A potential new class of heart failure therapeutics

Open Date: 2018-02-01

Close Date: 2019-04-01

Grant: Close

Myosin binding protein-C: a key regulator of cardiac output

Open Date: 2016-04-01

Close Date: 2022-03-01

Articles (18)

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2025

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2023

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2022

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2021

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2021

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2021

Collaborators (52)

Dustin Duncan

Assistant Professor

Brock University

CANADA

Thomas Kampourakis

Research Interests

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About

Recent Grants

Articles (18)

Functional Antagonism of Protein Kinase C and A Phosphorylation of Cardiac Myosin Binding Protein-C

Development of bifunctional fluorescent probes and their application to α-helix labelling

AI is a viable alternative to high throughput screening: a 318-target study

Synthesis and Biophysical Characterization of Fingolimod Derivatives as Cardiac Troponin Antagonists

Structural changes in troponin during activation of skeletal and heart muscle determined in situ by polarised fluorescence

Cardiac myosin binding protein-C phosphorylation as a function of multiple protein kinase and phosphatase activities

Missense mutations in the central domains of cardiac myosin binding protein-C and their potential contribution to hypertrophic cardiomyopathy

Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium

Basic science methods for the characterization of variants of uncertain significance in hypertrophic cardiomyopathy

Conversion of a Cardiac Muscle Modulator from an Inhibitor to an Activator

Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays

In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells

Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A

Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening

Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7

Microscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein C

A Potent Fluorescent Reversible-Covalent Inhibitor of Cardiac Muscle Contraction

The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle

Collaborators (52)

Dustin Duncan

Jadel M. Kratz

Iain Greig

Simon Ameer-Beg

Davide Maria Ferraris

Kavita Gadar

Nathan Merrill

Teemu Haikarainen

Giulia Girolimetti

Jiyoun Lee

Kenneth S. Campbell

Timothy O'Meara

Masfique Mehedi

Brian D. Sykes

GOKHAN CILDIR

Lori Walker

Alexander Cobb

Brandon Pressly

Gracjan Michlewski

Ashleigh Paparella

Alice Vrielink

Kayode Ojo

Evripidis Gavathiotis

Van Hung Vuong Le

Juan José Lasarte

Alexander Agoulnik

Angelo Taglialatela

William Kerr

Isin Cakir

Agnidipta Ghosh

Bert Tanner

Michael Shattock

Christian Weber

William Bradshaw

Deirdre Coombe

Van Chi Thai

Andrea Ilari

David Siderovski

Jonathan So

Kirsikka Musta

Charlene M. Kahler

Silvia Buroni

Ashley L St. John

Megan O'Mara

Rajkumar Verma

Robert Bradley

Yogesh Gupta

Chang Yoon Doh

John Bruning

William Brent Clayton

Jarrod Mousa

Martin St. Maurice

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