Yogesh Gupta
Associate Professor, with Tenure
United StatesResearch Interests
Explore related searches
Contact this professor
Get a free first email built on one of their papers, ready for you to edit and send yourself.
About
Yogesh Gupta is an Associate Professor with tenure at the University of Texas Health Science Center at San Antonio, USA. His research areas encompass gene expression regulation, cancer immunology, and the roles of RNA methylation in cancer growth. Recent articles focus on topics such as the Mettl3-Mettl14-Dnmt1 axis in embryonic stem cell differentiation and the implications of epitranscriptomics in cancer. He also explores innovative approaches in targeting cancer resistance mechanisms and viral replication.
Articles (16)
Year:
2025
Year:
2024
Year:
2024
Year:
2024
Year:
2023
Year:
2023
BRCA1-deficient cells have increased IRE1 RNase, which degrades multiple microRNAs. Reconstituting expression of one of these, miR-4638–5p, resulted in synthetic lethality in BRCA1-deficient cancer cells. We found that miR-4638-5p represses expression of TATDN2, a poorly characterized member of the TATD nuclease family. We discovered that human TATDN2 has RNA 3′ exonuclease and endonuclease activity on double-stranded hairpin RNA structures. Given the cleavage of hairpin RNA by TATDN2, and that BRCA1-deficient cells have difficulty resolving R-loops, we tested whether TATDN2 could resolve R-loops. Using in vitro biochemical reconstitution assays, we found TATDN2 bound to R-loops and degraded the RNA strand but not DNA of multiple forms of R-loops in vitro in a Mg2+-dependent manner. Mutations in amino acids E593 and E705 predicted by Alphafold-2 to chelate an essential Mg2+ cation completely abrogated this R-loop resolution activity. Depleting TATDN2 increased cellular R-loops, DNA damage and chromosomal instability. Loss of TATDN2 resulted in poor replication fork progression in the presence of increased R-loops. Significantly, we found that TATDN2 is essential for survival of BRCA1-deficient cancer cells, but much less so for cognate BRCA1-repleted cancer cells. Thus, we propose that TATDN2 is a novel target for therapy of BRCA1-deficient cancers.
Year:
2023
Year:
2023
Year:
2022
Year:
2022
Year:
2022
Year:
2022
Year:
2021
Year:
2021
Year:
2020
Year:
2020
Collaborators (51)
Dustin Duncan
Assistant Professor
Brock University
Jadel M. Kratz
Head of Discovery and Partnerships LATAM
-
Iain Greig
University of Aberdeen
Davide Maria Ferraris
Associate Professor
Università degli Studi del Piemonte Orientale
Kavita Gadar
University of Birmingham
Nathan Merrill
University of Michigan
Luis Martinez-Sobrido
Professor
Texas Biomedical Research Institute
Teemu Haikarainen
Tampere University
Giulia Girolimetti
Università del Salento
Jiyoun Lee
Professor
Sungshin Women's University
Timothy O'Meara
Harvard University
Masfique Mehedi
Assistant Professor
North Dakota State University
Kevin Ha
Head of Data Science, Genomics
-
GOKHAN CILDIR
University of South Australia
Brandon Pressly
Denali Therapeutics
Gracjan Michlewski
Professor
International Institute of Molecular and Cell Biology
Ashleigh Paparella
Lecturer
University of Sydney
Alice Vrielink
University of Western Australia
Kayode Ojo
University of Washington
Evripidis Gavathiotis
Professor
Albert Einstein College of Medicine
Van Hung Vuong Le
Københavns Universitet
Juan José Lasarte
Universidad de Navarra
Alexander Agoulnik
Florida International University
Angelo Taglialatela
Columbia University Irving Medical Center
juan De la Torre
Professor
Scripps Research Institute
William Kerr
Professor of Microbiology & Immunology
SUNY Upstate Medical University
Isin Cakir
Assistant Professor of Medicine
University of Pittsburgh
Agnidipta Ghosh
Albert Einstein College of Medicine
Christian Weber
Chair in Vascular Medicine and Physician-in-Chief
LMU Klinikum
William Bradshaw
University of Oxford
Deirdre Coombe
Professor
Curtin University
Van Chi Thai
University of Western Australia
Siyuan Zheng
Assistant Professor
University of Texas Health Science Center at San Antonio
Andrea Ilari
Istituto di Biologia e Patologia Molecolari Consiglio Nazionale delle Ricerche
David Siderovski
Professor and Chairman
University of North Texas Health Science Center
Shaun Olsen
Associate Professor
University of Texas Health Science Center at San Antonio
Jonathan So
Assistant Professor
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
Kirsikka Musta
Tampere University
Charlene M. Kahler
University of Western Australia
Silvia Buroni
Associate Professor
Università degli Studi di Pavia
Ashley L St. John
-
Olga Rechkoblit
Assistant Professor
Icahn School of Medicine at Mount Sinai
Megan O'Mara
Professor
University of Queensland
Rajkumar Verma
Assistant Professor
University of Connecticut School of Medicine
Robert Hromas
-
Robert Bradley
Full Professor
Fred Hutchinson Cancer Research Center
Thomas Kampourakis
Lecturer
King’s College London
John Bruning
Senior Lecturer
University of Adelaide
William Brent Clayton
Associate Research Professor of Medicine
Indiana University School of Medicine
Jarrod Mousa
Assistant Professor
University of Georgia
Martin St. Maurice
Associate Professor
Marquette University
ApplyKite TwinLearns as you applyMake your next move.
Prepare your application
Review drafts before you send them.