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Jussara Amato

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Associate Professor

University of Naples Federico II

Italy

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About

Dr. Jussara Amato is an Associate Professor at the University of Naples Federico II, Italy. Her research primarily focuses on the chemistry and biology of noncanonical nucleic acid structures, particularly G-quadruplexes and their therapeutic applications in cancer and neurodegenerative diseases. Recent publications include studies on G-quadruplex-forming aptamers and their interactions with mutant huntingtin protein.

Recent Grants

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Discovery of new ligands, specifically targeting bile acid receptors, for the treatment of liver and metabolic disorders

Open Date: 2017-01-01

Close Date:

Articles (11)

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2025

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2024

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2024

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2022

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2022

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2022

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2022

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2021

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2021

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2020

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2020

Collaborators (23)

George Kokotos

National and Kapodistrian University of Athens

GREECE

Jussara Amato

Research Interests

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About

Recent Grants

Articles (11)

Vincristine Beyond Mitosis: Uncovering a First Link to G-Quadruplex DNA in Cancer Cells

Chemistry and Biology of Noncanonical Nucleic Acid Structures: From Physicochemical Properties to Therapeutic Applications

Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions

Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders.

Combination of dl922-947 Oncolytic Adenovirus and G-Quadruplex Binders Uncovers Improved Antitumor Activity in Breast Cancer

Truncated Analogues of a G-Quadruplex-Forming Aptamer Targeting Mutant Huntingtin: Shorter Is Better!

Fighting the Huntington’s Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies

Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds

Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives

Collaborators (23)

George Kokotos

Bruno Pagano

Maurizio Pellecchia

Diego Muñoz-Torrero

Gian Cesare Tron

Roberta Rocca

Michael Gütschow

Domenica Capasso

Massimo Bertinaria

Anna Di Porzio

Bruno Catalanotti

Daniela Montesarchio

STEFANO MANGANI

Katalin Prokai-Tatrai

Giuseppe PORTELLA

Ivan Kosalec

Mariarosa AB Melone

diego brancaccio

Nunzia Iaccarino

Yasu-Taka Azuma

Francesco Saverio Di Leva

Peter Scott

Jarkko Rautio

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