Bruno Catalanotti

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Assistant Professor

University of Naples Federico II

Italy

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About

Bruno Catalanotti is an Assistant Professor at the University of Napoli Federico II, Italy. His research areas encompass the molecular and structural biology of cancer, Alzheimer's disease, and the interactions of signaling pathways, as evidenced by his recent articles on topics ranging from oncogenic pathways to novel drug discovery. His work also includes significant contributions to understanding the mechanisms underlying RNA-dependent RNA polymerase in SARS-CoV-2 and the role of bile acids in receptor antagonism.

Recent Grants

Grant: Close

Sviluppo di derivati degli acidi biliari come agenti antivirali

Open Date: 2020-01-01

Close Date: 2022-01-01

Grant: Close

SATIN-Development of Innovative Therapeutic Approaches for Treatment-Resistant Neoplastic Diseases

Open Date: 2019-01-01

Close Date: 2021-12-01

Articles (18)

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2024

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2022

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (16)

Bianca Fiorillo

Non-tenured Assistant Professor-RTDA

University of Naples Federico II

ITALY

Bruno Catalanotti

Research Interests

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About

Recent Grants

Articles (18)

Synthesis, biological evaluation and metadynamics simulations of novel N-methyl β-sheet breaker peptides as inhibitors of Alzheimer's β-amyloid fibrillogenesis

Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis

The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer

Author Correction: Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system

Exploring the DNA2-PNA heterotriplex formation in targeting the Bcl-2 gene promoter: A structural insight by physico-chemical and microsecond-scale MD investigation

Molecular and Structural Aspects of Clinically Relevant Mutations of SARS-CoV-2 RNA-Dependent RNA Polymerase in Remdesivir-Treated Patients

Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders

Ubiquitylation of BBSome is required for ciliary assembly and signaling

Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders.

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation

Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition

Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease

Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics

Combinatorial targeting of GPBAR1 and CYSLTR1 reveals a mechanistic role for bile acids and leukotrienes in drug induced liver injury

The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.

Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction.

Collaborators (16)

Bianca Fiorillo

Jussara Amato

Bruno Pagano

Ivan Conte

F. Javier Luque

Silvana Pedatella

Francesca Alessandra Ambrosio

Stefano Alcaro

Antonio Feliciello

Cristina Di Giorgio

Angela Zampella

Claudia Finamore

stefano fiorucci

Vittorio Limongelli

Giosuè Costa

Mauro De Nisco

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