Christian Frezza

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Professor of metabolomics in ageing

University of Cologne

Germany

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Professor Christian Frezza is a distinguished academic in the field of metabolomics in ageing at the University of Cologne, Germany. His recent research focuses on the metabolic implications in cancer, with publications addressing topics such as fumarate in cancer metabolism and the Warburg effect. Through innovative approaches like the Signature Regulatory Clustering model, he investigates mechanisms of phenotype regulation in renal cancer, contributing significantly to the understanding of tumor immunogenicity.

Recent Grants

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Investigation of the role of metabolism in tumorigenesis

Open Date: 2012-04-30

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Oncofum

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PFA

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Articles (19)

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2025

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2021

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2021

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2021

Collaborators (23)

VICTOR H. VILLAR

University of St. Andrews

UNITED KINGDOM

Christian Frezza

Research Interests

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Recent Grants

Articles (19)

Alternatively Spliced Citrate Synthase Supports Colorectal Cancer

Fumarate

Fine-tuning tumor immunogenicity with mitochondrial complex I

Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues

Functional implications of fumarate-induced cysteine succination

Presenting metabolomics analyses: what’s in a number?

SiRCle (Signature Regulatory Clustering) model integration reveals mechanisms of phenotype regulation in renal cancer

Fructose: the sweet(er) side of the Warburg effect

Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism

A century of the Warburg effect

Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells

Metabolic symbiosis in pancreatic cancer

The context-specific roles of urea cycle enzymes in tumorigenesis.

Neural stem cells traffic functional mitochondria via extracellular vesicles

Convergent somatic mutations in metabolism genes in chronic liver disease.

Genome and metabolome: chance and necessity

Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis

Control of endothelial quiescence by FOXO-regulated metabolites

Author Correction: Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis

Collaborators (23)

VICTOR H. VILLAR

Randall Johnson

Matthew Hoare

Heike Laman

Ayelet Erez

Emanuel Gonçalves

Christine Varon

Jakub Surmacki

Erika Fernandez-Vizarra

Tommaso Leonardi

Marco Castro

Piedad-del-Socorro Murdoch

Raúl V. Durán

May C. Morris

Karolina Chrabąszcz

Sarah Courtois

Carlo Viscomi

Amarnath Natarajan

Dylan G. Ryan

Jorge Andrade

Sarah Aitken

Sarah Bohndiek

Manuel Kaulich

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