Giandomenico Maggiore
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Articles (14)
Year:
2025
Year:
2024
Year:
2024
Year:
2024
Year:
2023
Year:
2023
Year:
2023
Year:
2023
The purpose of this study was to differentiate post-chemoradiotherapy (CRT) changes from tumor persistence/recurrence in early follow-up of naso-oropharyngeal carcinoma on magnetic resonance (MRI) with diffusion (DWI) and dynamic contrast-enhanced perfusion-weighted imaging (DCE-PWI). A total of 37 patients were assessed with MRI both for tumor staging and 4-month follow-up from ending CRT. Mean apparent diffusion coefficient (ADC) values, area under the curve (AUC), and K(trans) values were calculated from DWI and DCE-PWI images, respectively. DWI and DCE-PWI values of primary tumor (ADC, AUC, K(trans)pre), post-CRT changes (ADC, AUC, K(trans)post), and trapezius muscle as a normative reference before and after CRT (ADC, AUC, K(trans)muscle pre and muscle post; AUCpost/muscle post:AUCpre/muscle pre (AUCpost/pre/muscle); K(trans)post/muscle post:K(trans)pre/muscle pre (K(trans)post/pre/muscle) were assessed. In detecting post-CRT changes, ADCpost > 1.33 × 10−3 mm2/s and an increase >0.72 × 10−3 mm2/s and/or >65.5% between ADCpost and ADCpre values (ADCpost-pre; ADCpost-pre%) had 100% specificity, whereas hypointense signal intensity on DWIb800 images showed specificity 80%. Although mean AUCpost/pre/muscle and K(trans)post/pre/muscle were similar both in post-CRT changes (1.10 ± 0.58; 1.08 ± 0.91) and tumor persistence/recurrence (1.09 ± 0.11; 1.03 ± 0.12), K(trans)post/pre/muscle values < 0.85 and >1.20 suggested post-CRT fibrosis and inflammatory edema, respectively. In early follow-up of naso-oropharyngeal carcinoma, our sample showed that ADCpost > 1.33 × 10−3 mm2/s, ADCpost-pre% > 65.5%, and ADCpost-pre > 0.72 × 10−3 mm2/s identified post-CRT changes with 100% specificity. K(trans)post/pre/muscle values less than 0.85 suggested post-CRT fibrosis, whereas K(trans)post/pre/muscle values more than 1.20 indicated inflammatory edema.
Year:
2023
Year:
2023
Year:
2023
Year:
2022
Year:
2022
Year:
2022
Collaborators (66)
Mina Youssef
University of East Anglia
Enoch Akowuah
Professor
Newcastle University
Matteo Marro
Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino
Andreas Älgå
Associate Professor of Surgery
Karolinska Institutet Institutionen för klinisk forskning och utbildning Södersjukhuset
Michael Farrell
Assistant Professor of Surgery
-
YAMINI SUBRAMANI
Western University
Ariel Abeldaño
University of Helsinki
Shaikh Sanjid Seraj
Associate Lecturer
Anglia Ruskin University
Neil Merrett
Professor
University of Western Sydney
Marisa Domingues Santos
Professora Associada
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar
David Bosanquet
-
Jasper Stijns
Vrije Universiteit Brussel
Sivakumar Gananadha
Associate Professor
Australian National University
NICCOLO' DADDI
Associate Professor
University of Bologna
Adam Frankel
University of Queensland
Thomas Pinkney
University of Birmingham
Susana Gonzalez Suarez
Universitat Autònoma de Barcelona (UAB)
NIKOLAOS KIRIAKOPOULOS
CHIEF OF OBSTETRICS AND GYNECOLOGY CLINIC AT GENERAL MATERNAL HOSPITAL HELENA VENIZELOU
-
Cosimo Nardi
-
ida barca
University “Magna Græcia” of Catanzaro
Bijan Teja
University of Toronto
Nicola Colucci
Cambridge University Hospitals
Alvaro Sanchez Barrueco
Prof.
Universidad Alfonso X el Sabio
Georg Singer
Resident, Assistant Professor, Consultant, Associate Professor
Medical University of Graz
Chiara Lorini
University of Florence
Maria Giulia CRISTOFARO
Professore Associato di Chirurgia Maxillo-Facciale2
Universitá degli Studi Magna Græcia di Catanzaro Dipartimento di Medicina Sperimentale e Clinica
Mark Bremholm Ellebæk
Odense University Hospital
Jugpal Arneja
Clinical Professor
The University of British Columbia
Ignacio Javier Fernandez
Professore Associato in Otorinolaringoiatria
University of Bologna
Marc Vallve-Bernal
Associate Professor
Universitat Rovira i Virgili
Rebecka Hultgren
Karolinska Institutet
Mahesh Nagappa
Associate Professor
Western University
Victoriano Soria Aledo
Profesor Asociado
Universidad de Murcia Facultad de Medicina
Ioannis Siasios
Assistant Professor of Neurosurgery
University Hospital of Alexandroupolis
Andrea Melloni
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Robert K. Parker
-
Pawel Miotla
Professor
Medical University of Lublin
Cristina Costeira
Professor adjunto
Instituto Politécnico de Leiria
Giuliana Germinario
University of Bologna
OLGA MATEO-SIERRA
Instituto de Investigación Sanitaria Gregorio Marañón
Joao Goncalo Valverde
Academic Teaching Fellow
Royal Surrey County Hospital
Aneel Bhangu
University of Birmingham
JUAN-CARLOS GOMEZ-ROSADO
PROFESOR ASOCIADO ASCIS
Universidad de Málaga Facultad de Medicina
Maria P Ntalouka
Lecturer
-
Tom Abbott
NIHR Clinical Lecturer
Queen Mary University of London
Kai Yuen Wong
Cambridge University Hospitals NHS Foundation Trust
JAVIER MATA
Head of Department
La Paz University Hospital
Eloy Espin-Basany
Universitat Autònoma de Barcelona (UAB)
Alessia D’Amico
Psycho-Neurobiology master - Qualified lecturer
Sapienza University of Rome
Mohammed Shahait
-
GIAN MARCO PRUCHER
Consultant Oral, Maxillofacial, Head and Neck Surgeon
Azienda Ospedaliero-Universitaria Maggiore della Carità
Mohamed Otify
University of Liverpool
Anil Hormis
Professor / Consultant
-
Reza Motallebzadeh
Professor
University College London
Funlayo Odejinmi
-
Andrea Matucci
-
David Moszkowicz
Professor
-
Guy Stanley
University of Western Australia
Oreste Gallo
Head, Full Professor
University of Florence
Marios Ghobrial
Cambridge University Hospitals NHS Foundation Trust
Ignacio Miranda
Profesor asociado
Universidad Católica de Valencia San Vicente Mártir
Philipp Höhn
Ruhr-Universität Bochum
Placido Bruzzaniti
-
Achille Tarsitano
University of Bologna
Andrew Schache
Professor of Head & Neck Surgery
University of Liverpool
Antonio Mario Scanu
Associate professor
Università degli Studi di Roma Tor Vergata Facoltà di Medicina e Chirurgia
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