Placido Bruzzaniti

Italy

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Articles (10)

Glioblastoma is an aggressive brain tumor with an average life expectancy between 14 and 16 months after diagnosis. The Ki-67 labeling index (LI), a measure of cellular proliferation, is emerging as a prognostic marker in GBM. In this study, we investigated the ultrastructure of glioblastoma tissue from 9 patients with the same molecular profile (adult IDH wild-type glioblastoma, wild-type ATRX, and positive for TP53 expression, GFAP expression, and EGFR overexpression) to find possible ultrastructural features to be used as biomarkers and correlated with the only parameter that differs among our samples, the Ki-67 LI. Our main results were the visualization of the anatomical basis of astrocyte-endothelial cells crosstalk; the ultrastructural in situ imaging of clusters of hyperactivated microglia cells (MsEVs); the ultrastructural in situ imaging of microglia cells storing lipid vesicles (MsLVs); the ultrastructural in situ imaging of neoplastic cells mitophagy (NCsM). The statistical analysis of our data indicated that MsEVs and MsLVs correlate with the Ki-67 LI value. We can thus assume they are good candidates to be considered morphological biomarkers correlating to Ki-67 LI. The role of NCsM instead must be further evaluated. Our study findings demonstrate that by combining ultrastructural characteristics with molecular information, we can discover biomarkers that have the potential to enhance diagnostic precision, aid in treatment decision-making, identify targets for therapy, and enable personalized treatment plans tailored to each patient. However, further research with larger sample sizes is needed to validate these findings and fully utilize the potential of ultrastructural analysis in managing glioblastoma.

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (66)

Hisham Marwan

Associate Professor

University of Texas Medical Branch

UNITED STATES

Placido Bruzzaniti

Research Interests

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Articles (10)

Adult IDH Wild-Type Glioblastoma Ultrastructural Investigation Suggests a Possible Correlation between Morphological Biomarkers and Ki-67 Index

Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries.

External validation of the ruptured arteriovenous malformation grading scale (RAGS) in a multicenter adult cohort.

Casemix, management, and mortality of patients receiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a prospective observational cohort study

External validation and recalibration of an incidental meningioma prognostic model - IMPACT: protocol for an international multicentre retrospective cohort study.

Visual Aura Secondary to Supratentorial Lipomatous Meningioma: A Rare Case Report

En Bloc Resection of Solitary Brain Metastasis: The Role of Perilesional Edema.

Selection of new COVID-19 genotypes following mass vaccination: The Rotavirus model

Impact of Bacillus Calmette-Guérin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 infection.

Resilience of elective cancer surgery systems during COVID-19 lockdowns: an international, multicentre, prospective cohort study

Collaborators (66)

Hisham Marwan

Mina Youssef

Franz L Ricklefs

Enoch Akowuah

Gary Groot

Matteo Marro

Tiit Mathiesen

Michael Farrell

Pieter Steinkamp

Pierre-Alexandre Ferrero

YAMINI SUBRAMANI

Shaikh Sanjid Seraj

Giulia Cossu

Marisa Domingues Santos

David Bosanquet

Jasper Stijns

Marek Mandera

NICCOLO' DADDI

Rocío Fernández-Méndez

Adam Frankel

Giandomenico Maggiore

Matthew Bank

Thomas Pinkney

NIKOLAOS KIRIAKOPOULOS

Luigi Valentino Berra

Pietro Familiari

Pedro Alberto Silva

Nicola Colucci

Andrea Perera

Alvaro Sanchez Barrueco

Georg Singer

Ignacio Javier Fernandez

Marc Vallve-Bernal

Rebecka Hultgren

Mahesh Nagappa

Victoriano Soria Aledo

Ioannis Siasios

Andrea Melloni

Pawel Miotla

Cristina Costeira

OLGA MATEO-SIERRA

Joao Goncalo Valverde

Aneel Bhangu

JUAN-CARLOS GOMEZ-ROSADO

Maria P Ntalouka

Tom Abbott

Michał Krakowiak

Kai Yuen Wong

JAVIER MATA

Alessia D’Amico

Giuseppe Familiari

Mohammed Shahait

GIAN MARCO PRUCHER

Mohamed Otify

Anil Hormis

Chwanrow Baban

Reza Motallebzadeh

Funlayo Odejinmi

David Moszkowicz

Guy Stanley

Marios Ghobrial

Ignacio Miranda

Jordi Gonzàlez

Philipp Höhn