Guy Sauvageau

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Affiliated professor

Université de Montréal

Canada

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Guy Sauvageau is an affiliated professor at the University of Montreal, Canada. His research focuses on areas such as acute myeloid leukemia (AML), gene editing techniques in hematopoietic cells, and the molecular mechanisms underlying hematopoietic stem cell development. His recent articles explore the genetic factors influencing AML, the therapeutic potential of UM171, and strategies for immunotherapy targeting AML cell surface heterogeneity.

Recent Grants

Grant: Open

KBTBD4 determines key epigenetic marks that govern human hematopoietic stem cell self-renewal

Open Date: 2021-12-01

Close Date: 2027-06-01

Grant: Close

Bone marrow stem cell expansion with UM171: a better solution for patients and donors

Open Date: 2020-09-01

Close Date: 2022-02-01

Grant: Close

Interrogating and implementing Omics for precision medicine in Acute Myeloid Leukemia

Open Date: 2018-04-01

Close Date: 2022-03-01

Grant: Close

Collaboration IRIC/universités/industrie : découverte accélérée de thérapies innovantes pour un impact durable - Projet AML

Open Date: 2018-04-01

Close Date: 2022-03-01

Grant: Close

RUNX1 mutation sensitizes human AML to H3K27 hypomethylation: A step towards precision therapy

Open Date: 2018-02-01

Close Date: 2022-01-01

Articles (28)

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Collaborators (10)

Krystel Vincent

CANADA

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Jean-Philippe Gagne

Professionnel de recherche

Université Laval

CANADA

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Christian Brendel

UNITED STATES

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Jean Roy

Full professor

Université de Montréal

CANADA

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Jean-Sébastien Delisle

Associate-professor

Université de Montréal

CANADA

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Guy Poirier

Professor

CANADA

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Martin Smith

Assistant Professor

Centre Hospitalier de l'Université de Montréal Centre de Recherche

CANADA

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Patrick Gendron

Institute of Cancer Research

CANADA

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Tatsuya Morishima

Lecturer

Kumamoto University

JAPAN

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Gregory Ehx

University of Liege

BELGIUM

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Guy Sauvageau

Research Interests

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Recent Grants

Articles (28)

Replication of a GWAS signal near HLA-DQA2 with AML using a disease-only cohort and external population-based controls

CoREST in pieces: dismantling the CoREST complex for cancer therapy and beyond

Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216

DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML

KBTBD4-mediated reduction of MYC is critical for hematopoietic stem cell expansion upon UM171 treatment

SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia

UM171 enhances fitness and engraftment of gene modified hematopoietic stem cells from sickle cells disease patients.

Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML.

Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia.

Immunotherapeutic targeting of surfaceome heterogeneity in AML.

Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells.

GPRC5C drives branched-chain amino acid metabolism in leukemogenesis

Improved outcomes of UM171–expanded cord blood transplantation compared with other graft sources: real-world evidence

Towards clinically meaningful expansion of human HSCs

Bortezomib maintenance after allogeneic transplantation in newly diagnosed myeloma patients results in decreased incidence and severity of chronic GVHD

Impact of Implementing a Bendamustine-based Conditioning Regimen on outcomes of Autologous Stem Cell Transplant in Lymphoma while Novel Cellular Therapies Emerge

Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair.

UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.

HLF Expression Defines the Human Hematopoietic Stem Cell State.

A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.

Overexpression of CD200 is a Stem Cell-Specific Mechanism of Immune Evasion in AML.

Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.

Newly diagnosed multiple myeloma patients treated with tandem auto‐allogeneic stem cell transplant have better overall survival with similar outcomes at time of relapse compared to patients who received autologous transplant only

Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors.

Collaborators (10)

Krystel Vincent

Jean-Philippe Gagne

Christian Brendel

Jean Roy

Jean-Sébastien Delisle

Guy Poirier

Martin Smith

Patrick Gendron

Tatsuya Morishima

Gregory Ehx

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