Henry Kranzler

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Professor

University of Pennsylvania

United States

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Henry Kranzler is a Professor at the University of Pennsylvania, USA. His research primarily focuses on the genetic and environmental factors influencing substance use disorders, particularly alcoholism and opioid use disorder. Recent articles highlight his work on polygenic risk factors, the impact of childhood adversity, and the integration of advanced frameworks to understand psychopathology.

Recent Grants

Grant: Close

Pharmacogenetic Analysis of Topiramate Treatment of AUD

Open Date: 2014-08-15

Close Date: 2019-07-31

Grant: Close

Placebo-controlled trial of bupropion for smoking cessation in pregnant women

Open Date: 2014-08-15

Close Date: 2019-07-31

Grant: Close

ABI Innovation: An Integrative Approach to Identifying Highly Heritable Subtypes of Complex Phenotypes

Open Date: 2014-07-01

Close Date: 2017-06-30

Grant: Close

2/2 Pharmacogenetic Treatment for Alcoholism

Open Date: 2012-05-25

Close Date: 2017-03-31

Grant: Close

Deep sequencing studies for cannabis and stimulant dependence

Open Date: 2010-09-30

Close Date: 2015-05-31

Articles (20)

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2023

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2022

Collaborators (14)

Emily E. Hartwell

UNITED STATES

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Joseph Deak

Yale University School of Medicine

UNITED STATES

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Amy Justice

Professor

Yale University School of Medicine

UNITED STATES

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Daniel Levey

Assistant Professor

Yale University

UNITED STATES

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Rachel Kember

Research Assistant Professor

University of Pennsylvania

UNITED STATES

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Emma C. Johnson

UNITED STATES

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Zhenhao Shi

Assistant Professor

University of Pennsylvania Perelman School of Medicine

UNITED STATES

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Anthony Santoro

Columbia University

UNITED STATES

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Katie Witkiewitz

UNITED STATES

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Yousef Khan

University of Pennsylvania

UNITED STATES

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Jackson SooHoo

University of Pennsylvania

UNITED STATES

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Joel Gelernter

Professor

Yale University School of Medicine

UNITED STATES

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Corinde Elsenoor Wiers

Assistant Professor

University of Pennsylvania

UNITED STATES

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Sarah Hartz

Assistant Professor

Washington University in Saint Louis School of Medicine

UNITED STATES

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Henry Kranzler

Research Interests

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Recent Grants

Articles (20)

Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use

Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology

Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology

Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms

Moderation of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate

Social network alcohol use is associated with individual‐level alcohol use among Black sexually minoritized men and gender‐expansive people: Findings from the Neighborhoods and Networks (N2) cohort study

A single-cell genomic atlas for the effects of chronic ethanol exposure in the mouse dorsal striatum

Communication-efficient federated learning of temporal effects on opioid use disorder with data from distributed research networks

Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity

Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity – ERRATUM

Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study

Demographic differences in the cascade of care for unhealthy alcohol use: A cross‐sectional analysis of data from the 2015–2019 National Survey on Drug Use and Health

Does polygenic risk for substance‐related traits predict ages of onset and progression of symptoms?

Medications for treating alcohol use disorder: A narrative review

An intensive longitudinal examination of topiramate treatment for alcohol use disorder: a secondary analysis of data from a randomized controlled trial

Metabolic Profiles Associated with Opioid Use and Opioid Use Disorder: a Narrative Review of the Literature

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

Effects of topiramate therapy on serum bicarbonate concentration in a sample of 10,279 veterans

Announcing a name change for ACER

Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits

Collaborators (14)

Emily E. Hartwell

Joseph Deak

Amy Justice

Daniel Levey

Rachel Kember

Emma C. Johnson

Zhenhao Shi

Anthony Santoro

Katie Witkiewitz

Yousef Khan

Jackson SooHoo

Joel Gelernter

Corinde Elsenoor Wiers

Sarah Hartz

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