Joel Gelernter

Professor

Yale University School of Medicine

United States

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About

Joel Gelernter is a Professor at Yale University School of Medicine, United States. His research focuses on the genetic underpinnings of substance use disorders, including alcohol dependence and treatment responses, utilizing advanced methodologies such as polygenic scores and machine learning. Recent publications highlight his contributions to understanding the shared genetic architecture of psychopathology and the interplay between genetic factors and environmental influences on substance use.

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Collaborators (22)

Renato Polimanti

Yale University School of Medicine

UNITED STATES

Joel Gelernter

Research Interests

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Articles (28)

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations

Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches

Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology

Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology

Predicting treatment-seeking status for alcohol use disorder using polygenic scores and machine learning in a deeply-phenotyped sample

Multi-ancestry genome-wide association meta-analysis of buprenorphine treatment response

Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Differences and similarities between the genetic architecture of lifetime substance use across different substances

Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits

Association patterns of antisocial personality disorder across substance use disorders

Genetic and non-genetic predictors of risk for opioid dependence

Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression

Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge

Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits

Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

Multi‐omics cannot replace sample size in genome‐wide association studies

Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study

Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex

Polygenic risk score for problematic alcohol use predicts heavy drinking and alcohol use disorder symptoms in young adulthood after accounting for adolescent alcohol use and parental alcohol use disorder

Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort

Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits

Exploring the genetic overlap between twelve psychiatric disorders

Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells

Collaborators (22)

Renato Polimanti

Marco Galimberti

Christiaan de Leeuw

Joseph Deak

Amy Justice

Daniel Levey

Rachel Kember

Aliza Wingo

Huiping Zhang

Chadi Abdallah

Philip Jansen

Arpana Agrawal

Henry Kranzler

Murray Stein

Yousef Khan

Jackson SooHoo

Sophie van der Sluis

Hyeokmoon Kweon

Josefin Werme

Peter Na

Max Lam

Ryan Bogdan

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