Rachel Kember

Research Assistant Professor

University of Pennsylvania

United States

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About

Rachel Kember is a Research Assistant Professor at the University of Pennsylvania, USA. Her research focuses on the genetic and biological mechanisms underlying substance use disorders and alcohol use, as evidenced by her recent articles on genotype interactions, treatment responses, and genetic architecture related to psychopathology. She employs multi-ancestry approaches to analyze complex traits and the implications for clinical care.

Articles (22)

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Collaborators (21)

Renato Polimanti

Yale University School of Medicine

UNITED STATES

Rachel Kember

Research Interests

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About

Articles (22)

Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology

Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology

Multi-ancestry genome-wide association meta-analysis of buprenorphine treatment response

Genotype‐by‐sex interaction analyses for alcohol use disorder across biobanks

Moderation of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate

Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits

Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors

A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program

Considerations for the application of polygenic scores to clinical care of individuals with substance use disorders

Divergent gene expression patterns in alcohol and opioid use disorders lead to consistent alterations in functional networks within the dorsolateral prefrontal cortex

Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population

Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits

The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction

Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function

High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease

Genetic liability for substance use associated with medical comorbidities in electronic health records of African‐ and European‐ancestry individuals

Collaborators (21)

Renato Polimanti

Emily E. Hartwell

Joseph Deak

Amy Justice

Katherine Nathanson

Daniel Levey

Ditte Demontis

Emma C. Johnson

John Blangero

Christopher Rentsch

Henry Kranzler

Yousef Khan

Tiffany Love

Joel Gelernter

Fernando S. Goes

Frank Wendt

Daniel da Silva

Sarah Hartz

Theodore G. Drivas

Maria Niarchou

Vincent Koppelmans

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