James O'Donnell

Prof Vascular Biology

Royal College of Surgeons in Ireland

Ireland

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Professor James O'Donnell is a faculty member in Vascular Biology at the Royal College of Surgeons in Ireland. His research focuses on the roles of von Willebrand factor, glycopeptides, and their implications in various conditions, including sickle cell disease and bleeding disorders. His recent publications explore novel anticoagulant functions and endothelial dysfunction, contributing significantly to the field of vascular biology.

Articles (17)

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2025

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2023

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2023

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2023

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2023

Collaborators (14)

Emily Day

Assistant Professor

University of Western Ontario

CANADA

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Siobhan Glavey

Royal College of Surgeons in Ireland

IRELAND

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Roger Preston

Lecturer in Vascular Biology

IRELAND

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Megan Kennedy

IRELAND

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David O'Connell

Associate Professor

Dublin City University

IRELAND

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Emma Creagh

Associate Professor

Trinity College Dublin

IRELAND

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Padraic Fallon

Professor of Translational Immunology

Trinity College Dublin School of Medicine

IRELAND

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Michelle Lavin

UNITED KINGDOM

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Mieszko Wilk

Assistant Professor

Jagiellonian University

POLAND

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Ingmar Schoen

Lecturer

Royal College of Surgeons in Ireland

IRELAND

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Mike Laffan

UNITED KINGDOM

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Hauke Weiss

Trinity College Dublin

IRELAND

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Michael Carty

Trinity College Dublin

IRELAND

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Gavin McManus

Trinity College Dublin

IRELAND

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James O'Donnell

Research Interests

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Articles (17)

Decoration of gold nanoparticles with glycopeptides leads to a lower cellular uptake and liver retention

O-glycan determinants regulate VWF trafficking to Weibel-Palade bodies

Novel functions for von Willebrand factor

Synovitis and joint health in patients with haemophilia: Statements from a European e‐Delphi consensus study

Low von Willebrand Disease: A Bleeding Disorder of Unknown Cause?

A cross-sectional follow-up study of physical activity in adults with moderate and severe haemophilia

An expert consensus to define how higher standards of equitable care for von Willebrand disease can be achieved in the UK and Republic of Ireland

Corrigendum to Examining international practices in the management of pregnant women with von Willebrand disease [J Thromb Haemost. 2022 Jan;20(1):82-91] (Journal of Thrombosis and Haemostasis (2022) 20(1) (82–91), (S1538783622027416), (10.1111/jth.15561))

Elevated von Willebrand factor levels in multiple myeloma: dysregulated mechanisms of both secretion and clearance

Endothelial cell activation, Weibel-Palade body secretion, and enhanced angiogenesis in severe COVID-19

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance

Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia A is due to variability in the clearance of endogenous von Willebrand factor

Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice - Brief Report

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.

VWF-ADAMTS13 axis dysfunction in children with sickle cell disease treated with hydroxycarbamide vs blood transfusion.

Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.

Enhanced thrombin generation potential and endothelial dysfunction in chronic spontaneous urticaria.

Collaborators (14)

Emily Day

Siobhan Glavey

Roger Preston

Megan Kennedy

David O'Connell

Emma Creagh

Padraic Fallon

Michelle Lavin

Mieszko Wilk

Ingmar Schoen

Mike Laffan

Hauke Weiss

Michael Carty

Gavin McManus

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