Padraic Fallon

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Professor of Translational Immunology

Trinity College Dublin School of Medicine

Ireland

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Professor Padraic Fallon is a faculty member at the University of Dublin Trinity College School of Medicine, Ireland. His research primarily focuses on translational immunology, with recent articles exploring the impact of obesity on skin barrier function, the role of PD-L1 in regulating Treg cells in colorectal tumorigenesis, and the involvement of neutrophils in severe COVID-19. Additionally, his work addresses type-2 immune responses in allergic lung inflammation and the mechanisms underlying eosinophilic inflammation.

Recent Grants

Grant: Close

Immunomodulators for obesity

Open Date: 2017-11-01

Close Date: 2019-10-01

Grant: Close

Irish Personalized Approach to the Treatment of Haemophilia (iPATH)

Open Date: 2017-01-01

Close Date: 2022-03-01

Grant: Close

Targeting Bile Acids for Treatment of Inflammatory Bowel Disease

Open Date: 2016-01-01

Close Date: 2018-12-31

Grant: Close

Novel biotherapeutics for treatment of fibrosis.

Open Date: 2014-11-01

Close Date: 2018-11-01

Grant: Close

Development of a novel anti-inflammatory nanoparticle for the treatment of Acute Lung Injury

Open Date: 2012-07-31

Close Date: 2015-08-30

Padraic Fallon

Research Interests

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About

Recent Grants

Articles (22)

Obesity Impairs Skin Barrier Function and Facilitates Allergic Sensitization in Mice

4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development.

PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus.

Type 2 innate lymphoid cells are not involved in mouse bladder tumor development.

PD-L1 restrains PD-1&lt;sup&gt;+&lt;/sup&gt;Nrp1&lt;sup&gt;lo&lt;/sup&gt; Treg cells to suppress inflammation-driven colorectal tumorigenesis.

Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19.

Mef2d potentiates type-2 immune responses and allergic lung inflammation.

Retinoic Acid–Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation

IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases.

Characterisation of the pro-inflammatory cytokine signature in severe COVID-19

Th2‐dependent disappearance and phenotypic conversion of mouse alveolar macrophages

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.

Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report.

Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment

Association between metabolic syndrome and risk of both prevalent and incident frailty in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA).

von Willebrand factor links primary hemostasis to innate immunity.

Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation.

Association between vitamin D deficiency and the risk of prevalent type 2 diabetes and incident prediabetes: A prospective cohort study using data from The Irish Longitudinal Study on Ageing (TILDA).

An examination of the prevalence of metabolic syndrome in older adults in Ireland: Findings from The Irish Longitudinal Study on Ageing (TILDA).

Ly6C hi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology

Obesity-Mediated Immune Modulation: One Step Forward, (Th)2 Steps Back.

The IL-1 cytokine family as custodians of barrier immunity.

Collaborators (20)

Kamal Dua

Emily Day

Roger Preston

Axel Dietschmann

László Kupcsik

C. Schwartz

Roman Romero-Ortuno

James O'Donnell

David Munn

Emma Creagh

Nollaig Bourke

Kensuke Miyake

Mieszko Wilk

Richard Kim

Rose Anne Kenny

Hauke Weiss

David Voehringer

Michael Carty

Annie Curtis

Gavin McManus

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PD-L1 restrains PD-1<sup>+</sup>Nrp1<sup>lo</sup> Treg cells to suppress inflammation-driven colorectal tumorigenesis.