Emily Day

Assistant Professor

University of Western Ontario

Canada

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About

Emily Day is an Assistant Professor at the University of Western Ontario. Her research focuses on trained immunity, myeloid cell hypercoagulability, and the role of metabolic pathways in immune responses. Recent articles highlight her work on mitochondrial functions in immune evasion, the regulation of inflammation by macrophages, and the metabolic implications of various compounds on immune cell activity. She is based in Canada (+11).

Articles (14)

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2025

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2021

Collaborators (17)

Edmund Gilbert

Lecturer

Royal College of Surgeons in Ireland

IRELAND

Emily Day

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Articles (14)

Trained Immunity Causes Myeloid Cell Hypercoagulability

Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion

Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans

Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis

Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase.

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice

4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2

The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils.

The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids.

Protein targeting by the itaconate family in immunity and inflammation

Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site

Salsalate reduces atherosclerosis through AMPKβ1 in mice

Collaborators (17)

Edmund Gilbert

Roger Preston

Geoff Werstuck

judith coppinger

Bernardo (Dino) L. Trigatti

Luke O'Neill

Kei Sakamoto

James O'Donnell

Emma Creagh

Padraic Fallon

Mieszko Wilk

Dylan G. Ryan

David Finlay

Hauke Weiss

Vanessa P. Houde

Michael Carty

Gavin McManus

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