Jeroen Demmers

Associate Professor | Director of the Proteomics Core Facility

Erasmus MC

Netherlands

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Jeroen Demmers is an Associate Professor and Director of the Proteomics Core Facility at Erasmus MC in the Netherlands. His research focuses on proteomics, cellular mechanisms in cytokinesis, and the role of ubiquitin ligases in transcriptional regulation. He has contributed to significant studies involving immune responses and disease progression in various conditions, including acute myeloid leukemia and autosomal dominant polycystic kidney disease.

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Collaborators (25)

Xiaoke Yin

King’s College London

UNITED KINGDOM

Jeroen Demmers

Research Interests

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Articles (20)

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels

KIF2A stabilizes intercellular bridge microtubules to maintain mouse embryonic stem cell cytokinesis

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design

Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses

Transcription-coupled DNA-protein crosslink repair by CSB and CRL4<sup>CSA</sup>-mediated degradation.

Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2

Matrix Metalloproteinase-7 in Urinary Extracellular Vesicles Identifies Rapid Disease Progression in Autosomal Dominant Polycystic Kidney Disease

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency.

Modelling metastatic colonization of cholangiocarcinoma organoids in decellularized lung and lymph nodes

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination.

Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability.

Characterization of the TBR1 interactome: variants associated with neurodevelopmental disorders disrupt novel protein interactions.

Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control.

Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy.

Tumor decellularization reveals proteomic and mechanical characteristics of the extracellular matrix of primary liver cancer.

Extracellular matrix analysis of fibrosis: A step towards tissue engineering for urethral stricture disease.

USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3.

Bio-distribution and longevity of mesenchymal stromal cell derived membrane particles.

Collaborators (25)

Xiaoke Yin

Jacqueline Jacobs

Gijsje Koenderink

Monique Verstegen

Anja Groth

Heura Domènech Garcia

NITIKA TANEJA

Rachel Schot

Yaser Atlasi

Mattia Falcone

Wilfred van IJcken

Manuel Mayr

Eva van Rooij

Sonja Buschow

Oskar Rosmark

Román González-Prieto

Jordy Dekker

Hannes Lans

Milena Bellin

C. Peter Verrijzer

Danny Huylebroeck

Cristina Gontan

Ole N. Jensen

Peter van der Spek

Johan A. Slotman

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