J.G.C. van Hasselt

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Associate professor

Leiden University

Netherlands

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About

J.G.C. van Hasselt is an Associate Professor at Universiteit Leiden, Netherlands. His research focuses on antibiotic resistance dynamics in Pseudomonas aeruginosa, clinical pharmacokinetics of psychoactive substances, and the pharmacodynamics of interspecies interactions in polymicrobial infections. His recent publications include studies on colistin resistance, the impact of nutrient conditions on antimicrobial efficacy, and the pharmacokinetics of DMT and psilocin.

Recent Grants

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Collateral sensitivity-based antibiotic dose regimens to treat resistant bacterial infections

Open Date: 2019-03-01

Close Date: 2020-10-01

Grant: Close

Metabolomic fingerprint biomarkers to guide antibiotic therapy and reduce resistance development

Open Date: 2017-05-01

Close Date: 2021-05-01

Grant: Close

CARDIOTOX

Open Date: 2015-12-01

Close Date: 2018-11-01

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Collaborators (11)

elizabeth de lange

Professor in Predictive Pharmacology

NETHERLANDS

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Thomas Hankemeier

Professor at Leiden University

Leiden University

NETHERLANDS

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Laura Borghans

University of Maastricht

NETHERLANDS

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Tingjie Guo

Assistant Professor

Leiden University

NETHERLANDS

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Elke Krekels

Assistant Professor

Leiden University

NETHERLANDS

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Henning Bundgaard

Professor, senior consultant in cardiology

Copenhagen University Hospital

DENMARK

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Oana Ciofu

Københavns Universitet

DENMARK

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Henk-Jan Guchelaar

Leiden University Medical Center

NETHERLANDS

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Catherijne A J Knibbe

Leiden University

NETHERLANDS

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Laura Bertien Zwep

Assistant professor Statistics and Pharmacometrics

Leiden University

NETHERLANDS

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Robert Jansen

Assistant Professor

Radboud University

NETHERLANDS

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J.G.C. van Hasselt

Research Interests

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About

Recent Grants

Articles (28)

Nutrients drive the antibiotic-specific evolution of resistance in Pseudomonas aeruginosa

Colistin resistance dynamics in Pseudomonas aeruginosa under biofilm and planktonic growth

Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis

Correction: Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post‑Hoc Analysis

Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis

Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?

Pharmacodynamics of interspecies interactions in polymicrobial infections

Prolonged anoxic exposure impacts antibiotic sensitivity profiles of Pseudomonas aeruginosa

Nutrient conditions affect antimicrobial pharmacodynamics in Pseudomonas aeruginosa

Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis

Longitudinal metabolite profiling of Streptococcus pneumoniae-associated community-acquired pneumonia

Interplay of virulence factors shapes ecology and treatment outcomes in polymicrobial infections

Non‐linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix

Pharmacokinetic/pharmacodynamic model-based optimization of temocillin dosing strategies for the treatment of systemic infections

Quantitative modeling of tumor dynamics and development of drug resistance in non‐small cell lung cancer patients treated with erlotinib

Virtual Patient Simulation Using Copula Modeling

Model‐based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug‐resistant tuberculosis

Differential metabolic host response to pathogens associated with community-acquired pneumonia

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Evaluation of a Cardiovascular Systems Model for Design and Analysis of Hemodynamic Safety Studies

Evaluation of a Cardiovascular Systems Model for Design and Analysis of Hemodynamic Safety Studies

Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?

Attainment of Target Antibiotic Levels by Oral Treatment of Left-sided Infective Endocarditis: A POET Substudy

Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling

Rifampicin reduces plasma concentration of linezolid in patients with infective endocarditis

Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations

Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations

Collaborators (11)

elizabeth de lange

Thomas Hankemeier

Laura Borghans

Tingjie Guo

Elke Krekels

Henning Bundgaard

Oana Ciofu

Henk-Jan Guchelaar

Catherijne A J Knibbe

Laura Bertien Zwep

Robert Jansen

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