Kiminori Nakamura

Hokkaido University

Japan

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Articles (13)

Year:

2024

Year:

2024

Year:

2023

Year:

2022

Significance Paneth cells produce granules containing antimicrobial peptides, such as α-defensin for host defense. Examination of the production and utilization of fucosyltransferase 2 (Fut2) by Paneth cells revealed two distinct subsets: Fut2 + Paneth cells and Fut2 − Paneth cells. Compared with Fut2 − Paneth cells, Fut2 + Paneth cells were enriched in granules containing antimicrobial peptides. IL-22 and IL-17a were found to be essential for commensal bacteria-dependent Fut2 + Paneth cell development and function as part of gut defense.

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Collaborators (6)

Yuki Sato

Hokkaido University

JAPAN

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Shuya Ohira

Specially Appointed Assistant Professor

Hokkaido University

JAPAN

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Shingo Umemoto

Research Associate

Oita University

JAPAN

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Hiroshi Kiyono

University of Tokyo

JAPAN

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Akiko Tamakoshi

Hokkaido University

JAPAN

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Ryodai Yamamura

Assistant Professor

Hokkaido University

JAPAN

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Kiminori Nakamura

Research Interests

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Articles (13)

Development of an Evaluation System Using Intestinal Organoids for Drug Efflux Transport Analysis by an Imaging Approach

Potential consequences of phototoxicity on cell function during live imaging of intestinal organoids

Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production

Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study

Intestinal commensal microbiota and cytokines regulate Fut2<sup>+</sup>Paneth cells for gut defense

Efficient and simple genetic engineering of enteroids using mouse isolated crypts for investigating intestinal functions

Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study

Ingestion of miso regulates immunological robustness in mice

Ingestion of miso regulates immunological robustness in mice

Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense

Oral frailty and carriage of oral Candida in community-dwelling older adults (Check-up to discover Health with Energy for senior Residents in Iwamizawa; CHEER Iwamizawa)

Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption

Simultaneous real-time analysis of Paneth cell and intestinal stem cell response to interferon-γ by a novel stem cell niche tracking method

Collaborators (6)

Yuki Sato

Shuya Ohira

Shingo Umemoto

Hiroshi Kiyono

Akiko Tamakoshi

Ryodai Yamamura

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