Shingo Umemoto
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Research Associate
JapanResearch Interests
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Recent Grants
Grant: Close
好酸球性副鼻腔炎の病態におけるエンドカンナビノイドシステムの寄与についての研究
Open Date: 2019-04-01
Close Date: 2022-03-01
Grant: Close
好酸球性副鼻腔炎の病態におけるエンドカンナビノイドシステムの寄与についての研究
Open Date: 2019-04-01
Close Date: 2022-03-31
Grant: Close
Analysis of functional relationships of dendritic cells, NKT cells, and Th17 cells in upper respiratory mucosal immunity
Open Date: 2016-04-01
Close Date: 2018-03-01
Grant: Close
Analysis of functional relationships of dendritic cells, NKT cells, and Th17 cells in upper respiratory mucosal immunity
Open Date: 2016-04-01
Close Date: 2018-03-31
Grant: Close
上気道粘膜免疫におけるNKT細胞の機能解析と経鼻ワクチンへの応用
Open Date: 2013-04-01
Close Date: 2014-03-01
Articles (7)
Year:
2024
Year:
2023
Year:
2023
Significance Paneth cells produce granules containing antimicrobial peptides, such as α-defensin for host defense. Examination of the production and utilization of fucosyltransferase 2 (Fut2) by Paneth cells revealed two distinct subsets: Fut2 + Paneth cells and Fut2 − Paneth cells. Compared with Fut2 − Paneth cells, Fut2 + Paneth cells were enriched in granules containing antimicrobial peptides. IL-22 and IL-17a were found to be essential for commensal bacteria-dependent Fut2 + Paneth cell development and function as part of gut defense.
Year:
2022
Year:
2022
Year:
2021
Year:
2021
Collaborators (4)
Shin-ichi Sawada
Project Associate Professor
Chiba University
Kiminori Nakamura
Hokkaido University
Shuya Ohira
Specially Appointed Assistant Professor
Hokkaido University
Hiroshi Kiyono
University of Tokyo
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