Shuya Ohira
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Specially Appointed Assistant Professor
JapanResearch Interests
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About
Shuya Ohira is a Specially Appointed Assistant Professor at Hokkaido University, Japan. His research focuses on the modulation of intestinal microbiota, the role of Paneth cells, and the effects of phototoxicity on intestinal organoids. Recent articles include studies on α-defensins and their impact on gut health, particularly in relation to nonalcoholic steatohepatitis and Crohn's disease.
Recent Grants
Grant: Close
α-Defensinの共生制御が担う腸を起点とする粘膜免疫ネットワーク
Open Date: 2022-04-01
Close Date: 2024-03-01
Grant: Close
小腸上皮細胞の環境因子との相互作用による生体恒常性維持機構の解明
Open Date: 2021-10-01
Close Date: 2022-04-01
Articles (8)
Year:
2025
Year:
2024
Year:
2023
Significance Paneth cells produce granules containing antimicrobial peptides, such as α-defensin for host defense. Examination of the production and utilization of fucosyltransferase 2 (Fut2) by Paneth cells revealed two distinct subsets: Fut2 + Paneth cells and Fut2 − Paneth cells. Compared with Fut2 − Paneth cells, Fut2 + Paneth cells were enriched in granules containing antimicrobial peptides. IL-22 and IL-17a were found to be essential for commensal bacteria-dependent Fut2 + Paneth cell development and function as part of gut defense.
Year:
2022
Year:
2022
Year:
2021
Year:
2020
Year:
2020
Collaborators (4)
Kiminori Nakamura
Hokkaido University
Shingo Umemoto
Research Associate
Oita University
Hiroshi Kiyono
University of Tokyo
Tomoyasu Aizawa
Professor
Hokkaido University
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