Li Chan

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Professor of Molecular Endocrinology and Metabolism/Honorary Consultant in Paediatric Endocrinology

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United Kingdom

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About

Li Chan is a Professor of Molecular Endocrinology and Metabolism and an Honorary Consultant in Paediatric Endocrinology at Queen Mary University of London, William Harvey Research Institute. Based in the UK, Dr. Chan's research areas include metabolic dysfunction, type 2 diabetes in people with intellectual disabilities, and genetic factors in adrenal insufficiency. His recent publications reflect a strong focus on the intersection of endocrine health and complex diseases, particularly in pediatric populations and individuals with unique genetic backgrounds.

Recent Grants

Grant: Open

Cell DIVE Imager for automated, single cell, multiplexed immunofluorescence microscopy

Open Date: 2021-11-20

Close Date: 2026-11-19

Li Chan

Research Interests

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About

Recent Grants

Articles (19)

Editorial: Endocrine insights into heart disease

Metabolic dysfunction over a life course key to healthy ageing inequality.

Type 2 diabetes mellitus in people with intellectual disabilities: Examining incidence, risk factors, quality of care and related complications. A population-based matched cohort study.

Novel recurrent mutations and genetic diversity in Sudanese children with adrenal insufficiency.

Rare disease gene association discovery in the 100,000 Genomes Project.

Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society.

Primary unilateral macronodular adrenal hyperplasia with concomitant glucocorticoid and androgen excess and KDM1A inactivation.

A Novel Maternally Inherited GNAS Variant in a Family With Hyperphagia and Obesity: 3 Cases

Bariatric surgery in children with obesity and type 2 diabetes.

Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records.

Rare forms of genetic paediatric adrenal insufficiency: Excluding congenital adrenal hyperplasia

Identification of a novel specific small-molecule melanocortin-2-receptor antagonist

Diabetes and Obesity in Down Syndrome Across the Lifespan: A Retrospective Cohort Study Using U.K. Electronic Health Records.

Platelet-derived growth factor D expression in adrenal cells is modulated by corticosteroids: putative role in adrenal suppression

Susceptibility to COVID-19 Diagnosis in People with Down Syndrome Compared to the General Population: Matched-Cohort Study Using Primary Care Electronic Records in the UK.

C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis.

Genetic Analysis of Pediatric Primary Adrenal Insufficiency of Unknown Etiology: 25 Years’ Experience in the UK

Missplicing due to a synonymous, T96= exonic substitution in the T-box transcription factor TBX19 resulting in isolated ACTH deficiency.

Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling

Collaborators (23)

Sarah Flanagan

Yasir Elhassan

Julius Jacobsen

Detlef Bockenhauer

Livia Carvalho

Alberto Costa

Albert C. M. Ong

Emma Chambers

Andrea Isidori

John Achermann

Andre Strydom

Bruno Ferraz-de-Souza

Katrin Koehler

Rathi Prasad

Gareth Sanger

Pratik Shah

Martin Gulliford

Eugenio Barone

Asaad Baksh

Carl Sheridan

Cristina Perez-Ternero

Dr. Aisah Aubdool

Adrian J. Hobbs

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