Marcin Poręba

Research Assistant (PhD Student) position at the Wrocław University of Science and Technology , Faculty of Chemistry, in the Department of Biological Chemistry and Bioimaging. The post is part of the PACMAN project, “Personalized antibody-drug conjugates activated by matrix metalloproteinases for solid tumors,” led by Marcin Poręba (Professor of WUST). The project aims to develop a new generation of antibody-drug conjugates that do not rely on internalization and are instead selectively activated in the extracellular tumor microenvironment by matrix metalloproteinases such as MMP-2, MMP-9, and MMP-14. The successful candidate will work on the synthesis of antibody-drug and antibody-fluorophore conjugates with different linker types, as well as the physicochemical characterization of the resulting compounds. The role is research-intensive and sits within a translational program aiming toward preclinical validation and, longer term, IND-level documentation and first-in-human progression. This is a PhD-level research opening (First Stage Researcher, R1) with a full-time contract at 7/8 FTE. The appointment is initially for 12 months , with the possibility of extension for another 18 months after positive evaluation, for a total of 30 months . The advertised salary is PLN 5,393 gross plus additional thirteenth salary. Eligibility highlights include a Master’s degree in Biotechnology, Chemistry, or a related field , enrolment in the Doctoral School, experience with basic synthetic techniques in chemistry or peptide chemistry, and experience with basic analytical techniques in organic chemistry. Strong English proficiency, teamwork, communication skills, and alignment with the team’s research goals are emphasized in the selection process. Applicants should submit the required documents by email to [email protected] and include the reference number As16/W3/08/2026_ENG in the subject line. The deadline is 9 September 2026, 23:55 (Europe/Warsaw). The university also highlights a supportive research environment, opportunities for academic development, teaching, and international cooperation.

Research Assistant (PhD Student) at Wrocław University of Science and Technology , Faculty of Pure and Applied Mathematics, within the PACMAN project: Personalized antibody-drug conjugates activated by matrix metalloproteinases for solid tumors . The project, led by Marcin Poręba, PhD, DSc, Prof. of WUST , focuses on developing a new class of antibody–drug conjugates (ADCs) that can be selectively activated in the solid tumor microenvironment by matrix metalloproteinases (MMP-2, MMP-9, MMP-14). The advertised role is a first-stage researcher position under the project, explicitly intended for a PhD student. The appointed researcher will work on collecting, integrating, cleaning, and exploring biomedical datasets from multiple sources, including clinical, histopathological, and RNA-seq data. The job also includes multivariate analysis, anomaly detection, clustering, and methods such as PCA and DBSCAN, plus support for database design, development, maintenance, and data normalization/standardization procedures. This is a full-time, temporary position for 12 months, with employment starting on 1 November 2026 . The salary is PLN 6,163.00 gross per month plus an additional thirteenth salary payment. Eligibility highlights include a master’s degree in Mathematics or a related discipline , enrolment in the Doctoral School, programming and data analysis skills in Python and/or R , knowledge of basic biostatistics, and familiarity with dimensionality reduction and clustering techniques. Excellent English is required. The announcement also notes compliance with the WIB Programme’s non-competition policy. Applications must be submitted by email to [email protected] no later than 16 September 2026, 23:55 (Europe/Warsaw) . The email subject should include the reference number AS1/W13/08/2026_ENG . Applicants may submit documents in Polish or English. The position is based in Wrocław, Poland , at the Wrocław University of Science and Technology. The post is presented within a translational biomedical research context with strong potential for preclinical development and further academic and industrial collaboration.

Research Assistant (PhD Student) at the Wrocław University of Science and Technology, Faculty of Chemistry, in the Department of Biological Chemistry and Bioimaging. This position is part of the PACMAN project: “Personalized antibody-drug conjugates activated by matrix metalloproteinases for solid tumors” . The project is led by Marcin Poręba (PhD, DSc, Prof. of WUST) and is hosted within the Virtual Research Institute (WIB), managed by Łukasiewicz Research Network – PORT. The research is focused on proteases involved in the development of solid tumors, especially matrix metalloproteinases and related proteolytic mechanisms. The work includes investigation of neutrophil heterogeneity based on protease activity, toxicity assessment of ADC conjugates toward neutrophils, recombinant protease substrate specificity analysis, and studies of proteases in cancer cells using chemical probes. The broader project aims to develop a new class of antibody-drug conjugates that can be selectively activated extracellularly in the tumor microenvironment without internalization. This is a full-time temporary research appointment at R1 level (First Stage Researcher), advertised as a PhD student position. The post runs for 12 months initially, with the possibility of extension by 32 months after positive performance evaluation, for a total of 44 months. The salary is PLN 5,393 gross per month plus an additional thirteenth salary. Eligibility highlights include a Master’s degree in Biotechnology, Chemistry, or a related field, enrolment in the Doctoral School, practical knowledge of cell biology and in vitro culture methods, experience with immune cells isolated from whole blood, and hands-on work with proteolytic enzymes and kinetic studies using recombinant proteins. Excellent English is required. Applicants should submit the required competition documents by email to [email protected] no later than 2026-09-09 23:55 (Europe/Warsaw). The application should reference As15/W3/08/2026_ENG . Required documents include a cover/application letter, CV, proof of degree, self-report on research/teaching/organisational activity, publication list, scientific internship list and descriptions, and the required personal-data and eligibility statements. The position is based in Wrocław, Poland, and offers a strong translational research environment with access to preclinical validation, interdisciplinary collaboration, and international exchange opportunities at a reputable technical university.

Wrocław University of Science and Technology is recruiting a Research Assistant (PhD Student) for the Faculty of Chemistry, specifically the Department of Biological Chemistry and Bioimaging, in the project “Personalized antibody-drug conjugates activated by matrix metalloproteinases for solid tumors” (PACMAN) . The project is led by Marcin Poręba, PhD, DSc, Prof. of WUST and is carried out within the Virtual Research Institute (WIB), managed by Łukasiewicz Research Network – PORT. The research focuses on developing a new class of antibody-drug conjugates (ADCs) that do not require internalization and are selectively activated extracellularly by matrix metalloproteinases MMP-2, MMP-9, and MMP-14 in the solid tumor microenvironment. The successful candidate will work on the synthesis of ADCs with different linker types , purity and structure characterization, and cellular studies on toxicity, intracellular activity, and internalization. This is a full-time, temporary PhD-level position (R1 First Stage Researcher) with a working time of 7/8 FTE . The appointment begins on 1 November 2026 and is offered for 12 months initially, with the possibility of extension for an additional 32 months after positive performance evaluation, for a total of 44 months . The salary is PLN 5,393 gross plus an additional thirteenth salary. Applicants should hold a Master’s degree or equivalent in Biotechnology, Chemistry, or a related field, and be enrolled in the Doctoral School . The post requires experience with basic synthetic techniques in chemistry or peptide chemistry, as well as basic analytical techniques in organic chemistry. Strong English proficiency, teamwork, communication skills, and a good fit with the team’s scientific direction are important. The call also emphasizes scientific and professional experience, publications, project participation, awards, references, international mobility, and alignment of development plans with the research team. Applications must be submitted by 9 September 2026, 23:55 (Europe/Warsaw) . Send the required documents by email to [email protected] and include the reference number As14/W3/08/2026_ENG in the subject line. Applications may be submitted in Polish or English. The recruitment is conducted as an open competition under HR Excellence in Research / OTM-R principles. This position offers the chance to contribute to a highly translational anticancer program with potential advancement toward TRL 6–8 , IND-level documentation, and future first-in-human studies. The role includes participation in comprehensive preclinical validation across in vitro, ex vivo, and in vivo research, and provides a strong environment for academic development, teaching opportunities, and international cooperation.