Martijn Riool

This fully funded PhD position is part of the Marie Skłodowska-Curie Actions Doctoral Network SHIELD (Strategies for Healing Implant-associated infections and Enhancing Longevity in Devices), hosted at the University Hospital Regensburg, Germany. The project, designated as Doctoral Candidate 9 (DC9), focuses on the development and biological evaluation of hydrogel-based systems for the localized delivery of bacteriophages or antimicrobial peptides (AMPs) to prevent and treat bacterial infections associated with bone conduction hearing implants (BCHI). The research will involve applying these advanced delivery systems to both metallic and polymeric surfaces, such as polymer healing caps, titanium abutments, and silicone-based devices commonly used in BCHI. The candidate will investigate the stability, release kinetics, and antibacterial efficacy of phages and AMPs against biofilm-forming pathogens using sophisticated in vitro models that closely mimic physiological conditions. Complementary in vivo studies will be conducted to assess therapeutic efficacy and host immune responses, providing a comprehensive understanding of the potential of these therapies in real-world clinical scenarios. The project is highly interdisciplinary, involving close collaboration with clinical and biomaterials experts, including Oticon Medical and Technische Universität Dresden, and offers research secondments at partner institutions for specialized training and skill development. The SHIELD network unites 26 institutions across 11 countries, creating a unique environment for interdisciplinary and translational research in infection biology, biomaterials, and medical device innovation. Doctoral candidates in the network benefit from structured training in scientific, technical, and transferable skills, as well as international mobility and exposure to both academic and industrial research settings. The overarching aim of SHIELD is to develop innovative, interdisciplinary solutions to prevent and treat implant-associated infections, a growing challenge due to antimicrobial resistance and the increasing use of medical implants in healthcare. Applicants must have a Master’s degree in a relevant field (biology, microbiology, biomedical sciences, pharmaceutical sciences, biotechnology, or related), with strong interest and experience in microbiology, infection biology, and biomaterials. Experience with microbial culture techniques, molecular biology, antimicrobial testing, biomaterials, and/or animal infection models is highly desirable. Excellent English communication skills, independence, analytical thinking, creativity, and a collaborative mindset are essential. The position is open to candidates of any nationality, provided they have not resided or conducted their main activity in Germany for more than 12 months in the three years immediately preceding recruitment, and have not been awarded a doctoral degree. The position is fully funded for 36 months, offering a competitive salary and allowances according to Marie Skłodowska-Curie / Innovative Training Networks rules. Applications must be submitted online with a motivation letter, CV, and references. For further information, candidates may contact Dr. Martijn Riool at [email protected]. This is an exceptional opportunity to join a leading European research network and contribute to the advancement of infection control and medical device safety.