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Jan Wouter Drijfhout

Leiden University Medical Center

Netherlands

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Research Interests

Microbiology

20%

Immunology

30%

Peptide Chemistry

40%

T Cell Biology

30%

Antimicrobial Peptide

30%

Antibiotic Discovery

20%

Nanomedicine

20%

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Articles11

Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections

Article Link

Year:

2023

CalcAMP: A New Machine Learning Model for the Accurate Prediction of Antimicrobial Activity of Peptides

Article Link

Year:

2023

Physical and Functional Characterization of PLGA Nanoparticles Containing the Antimicrobial Peptide SAAP-148

Article Link

Year:

2023

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

Article Link

Year:

2023

Where Electrostatics Matter: Bacterial Surface Neutralization and Membrane Disruption by Antimicrobial Peptides SAAP-148 and OP-145.

Article Link

Year:

2022

Human T cells recognize HLA-DP–bound peptides in two orientations

Article Link

Year:

2022

In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries

Article Link

Year:

2022

A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection

Article Link

Year:

2022

Membrane Activity of LL-37 Derived Antimicrobial Peptides against Enterococcus hirae: Superiority of SAAP-148 over OP-145

Article Link

Year:

2022

Synergism between the Synthetic Antibacterial and Antibiofilm Peptide (SAAP)-148 and Halicin

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Year:

2022

An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML

Article Link

Year:

2021

Collaborators13

Marieke Griffioen

Associate Professor

Leiden University Medical Center

NETHERLANDS

Tobias Eisenberg

Associate Professor

Graz University of Technology

AUSTRIA

Hanne Mørck Nielsen

Københavns Universitet

DENMARK

Tassilo Leo Alexander Wachsmann

Leiden University Medical Center

NETHERLANDS

I. Jedema

Leiden University Medical Center

NETHERLANDS

Mirjam H.M. Heemskerk

Associate professor, Head of Laboratory of experimental hematology

Leiden University Medical Center

NETHERLANDS

Sylvia Klodzinska

Københavns Universitet

DENMARK

Roman Koning

Assistant Professor

Leiden University Medical Center

NETHERLANDS

Martijn Riool

Director/Professor

University Hospital Regensburg

GERMANY

Nermina Malanovic

Graz University of Technology

AUSTRIA

Hendrik Veelken

NETHERLANDS

Gerard van Westen

Full Professor AI & Medicinal Chemistry

Leiden University

NETHERLANDS

Suzan H. M. Rooijakkers

University Medical Center Groningen

NETHERLANDS

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