Matthias Wielscher
Lecturer
Research Interests
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About
Matthias Wielscher is a Lecturer at the Medical University of Vienna, Austria. His research areas include inflammatory cytokines, chronic lung diseases, and genetic risk factors for various health conditions. Recent publications highlight his contributions to understanding the impact of the COVID-19 pandemic on epidemiology, the genetics of keratinocyte cancer, and the role of DNA methylation in cardio-respiratory diseases.
Articles (12)
The phageome in normal and inflamed human skin
Dysbiosis of skin microbiota drives the progression of atopic dermatitis (AD). The contribution of bacteriophages to bacterial community compositions in normal and inflamed skin is unknown. Using shotgun metagenomics from skin swabs of healthy individuals and patients with AD, we found 13,586 potential viral contiguous DNA sequences, which could be combined into 164 putative viral genomes including 133 putative phages. The Shannon diversity index for the viral metagenome-assembled genomes (vMAGs) did not correlate with AD. In total, we identified 28 vMAGs that differed significantly between normal and AD skin. Quantitative polymerase chain reaction validation of three complete vMAGs revealed their independence from host bacterium abundance. Our data indicate that normal and inflamed skin harbor distinct phageomes and suggest a causative relationship between changing viral and bacterial communities as a driver of skin pathology.
Year:
2023
Collaborators (46)
sailalitha bollepalli
University of Helsinki
Giuseppe Matullo
-
Benjamin Mullin
University of Western Australia
Karin Pfisterer
Reader in Tissue homeostasis, inflammation and immunity
Medical University of Vienna
Peter Kovacs
Leipzig University
Kaare Christensen
University of Southern Denmark
Raute Sunder-Plassmann
Associate Professor
Medical University of Vienna
Veikko Salomaa
Research Professor
National Institute for Health and Welfare
Kumaraswamy naidu Chitrala
Assistant Professor
University of Houston
Ayse Demirkan
Senior Lecturer
University of Surrey
Catherine John
University of Leicester
Simon Haworth
Academic , Consultant Senior Lecturer in Dental and Maxillofacial Radiology
University of Bristol
Alaitz Poveda
Assisstant Proffesor
University of the Basque Country
Esther Walton
Professor of Biological Psychology
University of Bath
Noha Yousri
Weill Cornell Medicine
Amy Jayne McKnight
The Queen's University Belfast
Yvonne Golightly
Professor and Assistant Dean for Research
-
Mette korre Andersen
Københavns Universitet
Heikki Koistinen
University of Helsinki
Gonneke Willemsen
University of Amsterdam
Jing Chen
Lecturer
University of Leicester
Roelof Smit
Københavns Universitet
Ioanna Panagiota Kalafati
Lecturer
University of Thessaly
Rodney Scott
Prof. of Medical Genetics
University of Newcastle Australia
Areti Papadopoulou
University College London
maria pina concas
Institute for Maternal and child health Irccs Burlo Garofolo
Stavroula Kanoni
Reader (Associate Professor) in Nutrigenetics and Cardiovascular Health
Queen Mary University of London
Louis Perusse
Laval University
esteban J parra
Professor
University of Toronto Mississauga
Martin Tobin
-
Igor Rudan
Professor and Joint Director of the Centre for Global Health and the WHO Collaborating Centre
University of Edinburgh
Alicia Huerta-Chagoya
Broad Institute
Henrik Vestergaard
Københavns Universitet
Terho Lehtimäki
University of Tampere
Birgit Willinger
Medical University of Vienna
Anu-Maria Loukola
University of Helsinki
Alexia Cardona
University of Cambridge
Rima Mustafa
University of Oxford
Teemu Palviainen
University of Helsinki
Raymond Noordam
Assistant Professor
Leiden University Medical Center
Kyong-Mi Chang
Professor of Medicine & Associate Chief of Staff for R&D
-
Anna Jonsson
Københavns Universitet
W. Weninger
Medical University of Vienna
John Beilby
University of Western Australia
Jukka Koskela
University of Helsinki
Mette Aadahl
Københavns Universitet
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