Michael Murphy

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Professor of Mitochondrial Redox Biology

University of Cambridge

United Kingdom

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About

Michael Murphy is a Professor of Mitochondrial Redox Biology at the University of Cambridge, UK. His research focuses on mitochondrial function and its implications in various health conditions, including fetal hypoxia, cardiovascular risk during pregnancy, and inflammatory diseases. He has recently authored articles investigating the roles of antioxidants, oxylipins, and mitochondrial superoxide production in therapeutic contexts.

Recent Grants

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Exploring mitochondrial metabolism in health and disease using targeted biological chemistry

Open Date: 2020-06-01

Close Date: 2025-05-31

Grant: Close

Mitochondrial metabolism and stress responses in neurophysiology and neurodegeneration: insights for Huntington’s disease

Open Date: 2019-12-01

Close Date:

Grant: Close

PERK modulation in Huntington’s Disease Neurodegeneration

Open Date: 2018-11-01

Close Date:

Grant: Close

Huntingtin proteostasis and mitochondrial dysfunction in Huntington’s Disease

Open Date: 2017-10-01

Close Date:

Grant: Close

Mitochondrial oxidative damage and human diseases

Open Date: 2017-03-01

Close Date: 2020-03-30

Articles (25)

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2022

Collaborators (44)

Per-Johan Jakobson

Professor

Karolinska Institutet

SWEDEN

Michael Murphy

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About

Recent Grants

Articles (25)

Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry

Acute oxygen sensing by arterial chemoreceptors with a mutant mitochondrial complex I <scp>ND6</scp> subunit lacking reverse electron transport

Antioxidants: powering the fight against fetal hypoxia

TRAM–LAG1–CLN8 family proteins are acyltransferases regulating phospholipid composition

Human mitochondrial glutathione transferases: Kinetic parameters and accommodation of a mitochondria-targeting group in substrates

Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart

ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels

In vivo mitochondria-targeted protection against uterine artery vascular dysfunction and remodelling in rodent hypoxic pregnancy

A break in mitochondrial endosymbiosis as a basis for inflammatory diseases

A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding

AICAR confers prophylactic cardioprotection in doxorubicin-induced heart failure in rats

Corrigendum to “A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding” [Redox Biol. 72 (2024) 103161](S221323172400137X)(10.1016/j.redox.2024.103161)

Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury

Mitochondrial complex I activity in microglia sustains neuroinflammation

Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring

In vivo measurement of mitochondrial ROS production in mouse models of photoreceptor degeneration

Preventing mitochondrial reverse electron transport as a strategy for cardioprotection

Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria‐Targeted Triphenylphosphonium Constructs

Rapid fractionation of mitochondria from mouse liver and heart reveals in vivo metabolite compartmentation

Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport

Native chemical ligation approach to sensitively probe tissue acyl-CoA pools

A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Collaborators (44)

Per-Johan Jakobson

Francisco Schopfer

Anna Nicolaou

William Fuller

Robin Ali

Bernard Gallez

Katja Menger

Richard Hartley

Alessandro Rolfo

Martin Giera

Edward A Dennis

Edmund Kunji

Pierre Sonveaux

Paolo Ettore Porporato

Gerhard Liebisch

Hiran Prag

Dino Giussani

Adrian Lapthorn

Irundika Dias

Angela Logan

Christine Winterbourn

Hisamichi Naito

Julijana Ivanisevic

Patricia Ortega Saenz

Charles N. Serhan

Lalita Ramakrishnan

Ulrike Garscha

Louis Schmidt

Bruce Freeman

Takashi Hato

Ruth Andrew

Helmut Sies

Michael Shattock

Dean Jones

Makoto Arita

Kimihiko Banno

Richard Southworth

Ameer Taha

Thomas Krieg

Oswald Quehenberger

Andres Cardenas

Giovanni Mann

Ivana Milic

Robert K Hofstetter

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