Charles N. Serhan

Professor and Center Director

Brigham and Women's Hospital and Harvard Medical School

United States

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About

Charles N. Serhan is a Professor and Center Director at Brigham and Women's Hospital-Harvard Medical School in the United States. His research focuses on the mechanisms of inflammation resolution, particularly through the study of pro-resolving mediators and their biosynthesis. Recent articles from his work include studies on the activation of formylpeptide receptors and the analysis of oxylipins using liquid chromatography-mass spectrometry.

Articles (24)

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2025

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2023

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2023

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2022

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2022

Collaborators (27)

Per-Johan Jakobson

Professor

Karolinska Institutet

SWEDEN

Charles N. Serhan

Research Interests

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About

Articles (24)

Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry

SiO2 nanoparticles as disruptors of endogenous resolution mechanisms of inflammatory responses that exacerbate pneumonia

On the Total Synthesis of 7,8(S,S)-Epoxy-17(S)-hydroxy-4(Z),9(E),11(E),13(Z),15(E),19(Z)-docosahexaenoic Acid Derivative

Formylpeptide receptors in GtoPdb v.2025.1

ALX/FPR2 Receptor Activation by Inflammatory (fMLFII) and Pro-resolving (LXA4 and RvD3) Agonists

Low-dose pro-resolving mediators temporally reset the resolution response to microbial inflammation

Biosynthesis of resolvin D1, resolvin D2, and RCTR1 from 7,8(S,S)-epoxytetraene in human neutrophils and macrophages

15‐epi‐lipoxin A5 promotes neutrophil exit from exudates for clearance by splenic macrophages

One-Year Effects of High-Intensity Statin on Bioactive Lipids: Findings From the JUPITER Trial

Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation

Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease

Assessment of the Physicochemical Properties of Ultrafine Particles (UFP) from Vehicular Emissions in a Commercial Parking Garage: Potential Health Implications

A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and saliva

Infectious neutrophil deployment is regulated by resolvin D4

Resolvin D1 prevents injurious neutrophil swarming in transplanted lungs

ALX/FPR2 Activation by Stereoisomers of D1 Resolvins Elucidating with Molecular Dynamics Simulation

Anti-Inflammatory and Pro-resolving Actions of the N-Terminal Peptides Ac2-26, Ac2-12, and Ac9-25 of Annexin A1 on Conjunctival Goblet Cell Function

Stereochemistry and functions of the new cysteinyl‐resolvin, 4S,5R‐RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes

Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of lipocalin-2 in mice

Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration

Stereocontrolled total synthesis of Resolvin D4 and 17(R)-Resolvin D4

Metabolization of Resolvin E4 by ω-Oxidation in Human Neutrophils: Synthesis and Biological Evaluation of 20-Hydroxy-Resolvin E4 (20-OH-RvE4)

Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators

Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1

Collaborators (27)

Per-Johan Jakobson

Francisco Schopfer

Anna Nicolaou

Stephania Libreros

Martin Giera

Edward A Dennis

Gerhard Liebisch

Irundika Dias

Gabrielle Fredman

Julijana Ivanisevic

Ulrike Garscha

Louis Schmidt

Nan Chiang

Bruce Freeman

Ruth Andrew

Nicos Petasis

Makoto Arita

Philip Demokritou

Ameer Taha

Olga Demler

G.Enrico Rovati

Oswald Quehenberger

Ru-Rong Ji

Michael Murphy

Ivana Milic

Trond V. Hansen

Robert K Hofstetter

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