Per-Johan Jakobson

Professor

Karolinska Institutet

Sweden

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Research Interests

Pharmacology

50%

Immunology

20%

Inflammatory Biology

70%

Immunometabolism

20%

Drug Formulation

20%

Chemical Biology

20%

Neuroprotection

20%

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Recent Grants

Grant: Open

Determination of the role of prostaglandins in inflammatory diseases with cardiovascular comorbidities, new treatment opportunities and clinical implications

Open Date: 2024-01-01

Close Date: 2026-12-31

Grant: Close

Towards precision prevention and early therapy for RA

Open Date: 2021-10-01

Close Date: 2024-12-31

Grant: Close

Stromal-cancer cell interplay and immunomodulatory functions of prostaglandin E2 in the tumor microenvironment, a novel target for therapeutic intervention

Open Date:

Close Date:

Articles10

High-mannose glycans from Schistosoma mansoni eggs are important for priming of Th2 responses via Dectin-2 and prostaglandin E2

Year:

2024

In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation

Year:

2024

Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis.

Year:

2024

NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling

Year:

2024

Microsomal prostaglandin E synthase-1 inhibition promotes shunting in arachidonic acid metabolism during inflammatory responses in vitro

Year:

2023

High‐content screening of drug combinations of an <scp>mPGES</scp>‐1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance

Year:

2023

Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples

Year:

2023

Synthesis and Biological Evaluation of Novel Paracetamol-Triazole Conjugates

Year:

2023

The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential.

Year:

2023

Editorial: Insights in inflammation pharmacology: 2022.

Year:

2023

Collaborators7

Cornelis Hokke

Professor

Leiden University Medical Center

NETHERLANDS

Jianyang Liu

Karolinska Institutet

SWEDEN

Lars Klareskog

Prof

Karolinska Institutet

SWEDEN

Karin Larsson

Karolinska Institutet

SWEDEN

Kristina Lend

Karolinska Institutet

SWEDEN

Marina Korotkova

PhD, Associate professor

Karolinska Institutet

SWEDEN

Stacy Gelhaus Wendell

Associate Professor

University of Pittsburgh

UNITED STATES

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