Michelle R. Arkin

University of California

United States

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Articles (21)

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2025

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Collaborators (12)

May H. Abdel Aziz

UNITED STATES

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Luc Brunsveld

Prof. at Eindhoven University of Technology

Eindhoven University of Technology

NETHERLANDS

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Matthew McCarroll

Professional Researcher

University of California, San Francisco

UNITED STATES

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Christian Ottmann

NETHERLANDS

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Adam Renslo

Professor

University of California, San Francisco

UNITED STATES

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Markella Konstantinidou

University of California, San Francisco

UNITED STATES

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Aimee W. Kao

University of California

UNITED STATES

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Peter Cossar

Eindhoven University of Technology

NETHERLANDS

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Mark Moasser

Professor

University of California, San Francisco

UNITED STATES

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Michael Keiser

Associate Professor

University of California, San Francisco

UNITED STATES

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Melanie Ott

Professor

University of California, San Francisco

UNITED STATES

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Martin Kampmann

University of Zurich

SWITZERLAND

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Michelle R. Arkin

Research Interests

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Articles (21)

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus-MPro inhibitors with potent in vivo efficacy

Stabilization of Native Protein–Protein Interactions with Molecular Glues: A 14-3-3 Case Study

Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues

14‐3‐3 Protein‐Protein Interactions: From Mechanistic Understanding to Their Small‐Molecule Stabilization

Deep phenotypic profiling of neuroactive drugs in larval zebrafish

Molecular glues for protein-protein interactions: Progressing toward a new dream

Synthetic autophagy receptor

Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach

The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions

Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation

Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model

Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency

LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface

Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein–Protein Interactions

Expression and purification of active human kinases using Pichia pastoris as a general-purpose host

Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

Expression and purification of active human kinases using Pichia pastoris as a general-purpose host

Reimagining dots and dashes: Visualizing structure and function of organelles for high-content imaging analysis

Collaborators (12)

May H. Abdel Aziz

Luc Brunsveld

Matthew McCarroll

Christian Ottmann

Adam Renslo

Markella Konstantinidou

Aimee W. Kao

Peter Cossar

Mark Moasser

Michael Keiser

Melanie Ott

Martin Kampmann

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