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Monika Głuch-Lutwin

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Assistant Professor / Researcher in Pharmacology

Jagiellonian University Medical College

Poland

Research Interests

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Recent Grants

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TRUPATH Technology in the Study of Signaling Selectivity of Biased 5-HT1A Receptor Agonists: The Role of G Protein Subunits

Open Date: 2024-01-01

Close Date: 2025-01-01

Grant: Close

Study of the interactions of novel compounds using xCELLigence technology with respect to 5-HT1A and D2 receptor activity

Open Date: 2024-01-01

Close Date: 2025-01-01

Grant: Close

First dual 'biased' agonists of serotonin 5-HT1A and dopamine D2 receptors – an innovative approach in the search for therapies for psychiatric disorders

Open Date: 2021-01-01

Close Date:

Grant: Close

Optimization and validation of a method for assessing the intrinsic activity of 5-HT1A receptor ligands based on inhibition of cAMP synthesis and calcium ion mobilization

Open Date: 2018-01-01

Close Date: 2019-01-01

Grant: Close

Optimization and validation of a method for assessing the intrinsic activity of 5-HT1A receptor ligands using the SureFire assay based on ERK protein phosphorylation

Open Date: 2017-01-01

Close Date: 2017-01-01

Articles (20)

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Collaborators (23)

Magdalena Kotańska

POLAND

Monika Głuch-Lutwin

Research Interests

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Recent Grants

Articles (20)

Rational Design, Synthesis and Pharmacological Evaluation of Chalcones as Dual-Acting Compounds—Histamine H3 Receptor Ligands and MAO-B Inhibitors

New chalcogen-optimized 1,3,5-triazines as dual 5-HT6R/FAAH modulators: A versatile approach to neurodegenerative disorders

Machine Learning‐Driven Discovery of GABA‐A Ligands with Pronounced Neuroprotective Efficacy and Resistance to P‐gp Efflux

Simultaneous modulation of 5-HT6 and SERT by MM394: a dual-target ligand providing neuroprotection against amyloid-β toxicity, memory preservation, and alleviation of BPSD symptoms

Targeting GABAergic Hypofunction Associated with Schizophrenia: Identification of α1β2γ2GABA-A Receptor Ligands with Neuroprotective and Antipsychotic Properties

Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT1AR Agonist with Superior Antidepressant and Antiparkinsonian Activity

Procognitive Potential of Neuroprotective Triazine 5-HT6 Receptor Antagonists Tested on Chronic Activity In Vivo in Rats: Computer-Aided Insight into the Role of Chalcogen-Differences on the Pharmacological Profile

Purine-2,6-dione-based multitarget-directed ligands inhibiting PDE/TRPA1/CHIT1 as a new approach for the treatment of COPD

JP-14: A Trace Amine-Associated Receptor 1 Agonist with Anti-Metabolic Disorder Potential

The first-in-class 1,3,5-triazine-derived dual 5-HT<sub>6</sub>R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment

β-Arrestins as Key Switches in GPCR Signaling: From Molecular Structure to Clinical Implications — a Narrative Review

Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease

First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer’s Disease

Novel 1-(1-Arylimiazolin-2-Yl)-3-Arylalkilurea Derivatives with Modulatory Activity on Opioid MOP Receptors

Anti-diabetes and neuroprotection potential and primary safety studies of Isatis tinctoria L. hydroalcoholic leaf extract

Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer’s Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors

Preferential Synaptic Type of GABA-A Receptor Ligands Enhancing Neuronal Survival and Facilitating Functional Recovery After Ischemic Stroke

Exploring Novel GSK-3β Inhibitors for Anti-Neuroinflammatory and Neuroprotective Effects: Synthesis, Crystallography, Computational Analysis, and Biological Evaluation

Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties

Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances

Collaborators (23)

Magdalena Kotańska

Monika Marcinkowska

Clemens Zwergel

Aldona Pietrzak

Marcin Kolaczkowski

Joanna Śniecikowska

Angelo Fumia

Artur Świerczek

Alicja Gawalska

Michał Juszczak

Agnieszka Zagórska

Sylwia Woźniak

Anna Wieckowska

Adam Bucki

Jarosław Handzlik

Anna Stasiak

Ewa Szymanska

Waldemar Wagner

Luca Piemontese

Dawid Gogola

Dariusz Matosiuk

Katarzyna Woźniak

Dorota Łażewska

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