Oleksandr Kapralov

University of Pittsburgh

United States

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Articles (16)

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2024

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2024

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2024

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2023

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2021

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2021

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2021

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2021

Collaborators (9)

Vladimir Tyurin

University of Pittsburgh

UNITED STATES

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Svetlana N Samovich

Assistant Professor

Columbia University

UNITED STATES

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Andrew VanDemark

University of Pittsburgh

UNITED STATES

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Haider H. Dar

University of Pittsburgh

UNITED STATES

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Qin Yang

University of Pittsburgh

UNITED STATES

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Karolina Mikulska-Ruminska

Assistant Professor

Nicolaus Copernicus University

POLAND

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Yulia Tyurina

University of Pittsburgh

UNITED STATES

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Andrew Amoscato

University of Pittsburgh

UNITED STATES

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Hülya Bayir

University of Pittsburgh

UNITED STATES

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Oleksandr Kapralov

Research Interests

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Articles (16)

Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death.

PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.

Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes

Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators

Formation of protein adducts with Hydroperoxy-PE electrophilic cleavage products during ferroptosis.

Vitamin E/Coenzyme Q-Dependent "Free Radical Reductases:" Redox Regulators in Ferroptosis.

Visualizing Cardiolipin In Situ with HKCL-1M, a Highly Selective and Sensitive Fluorescent Probe.

Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo.

Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs

Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome

Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death.

P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis.

NO<sup>●</sup> Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis

A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO<sup>•</sup> sabotage of theft-ferroptosis.

Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes.

Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS).

Collaborators (9)

Vladimir Tyurin

Svetlana N Samovich

Andrew VanDemark

Haider H. Dar

Qin Yang

Karolina Mikulska-Ruminska

Yulia Tyurina

Andrew Amoscato

Hülya Bayir

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