Rolf Groenwold

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Professor of Clinical Epidemiology

Leiden University Medical Center

Netherlands

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About

Rolf Groenwold is a Professor of Clinical Epidemiology at Leiden University Medical Center in the Netherlands. His research focuses on clinical epidemiology, particularly in areas such as confounding in observational studies, patient preference trials in oncology, and the impact of cardiovascular risk minimization measures on analgesic use. He has published extensively in topics including trial termination predictors, missing data in predictive models, and excess mortality during the COVID-19 pandemic.

Recent Grants

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LUMC fellowship

Open Date: 2017-10-01

Close Date: 2022-09-01

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For many statistical methods that are commonly used in medical research, it is assumed that observations are independent. However, when this assumption is violated, alternative methods may be needed. In this paper, we describe why an analysis that ignores the dependencies within the data may provide biased results and outline possible alternatives. This paper aims to create awareness among researchers, readers, and reviewers for this possible source of bias in medical research.

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Collaborators (30)

Satu J Siiskonen

Utrecht University

NETHERLANDS

Rolf Groenwold

Research Interests

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About

Recent Grants

Articles (28)

Bone marrow lesions and collateral ligament lesions are associated in interphalangeal joints with osteoarthritis: The Hand OSTeoArthritis in Secondary care cohort

Preventing confounding in observational studies in orthopedic trauma surgery through expert panels: a systematic review

Impact of diclofenac risk minimization measures addressing cardiovascular risk on analgesic use in musculoskeletal disorders

Addressing Missingness in Predictive Models That Use Electronic Health Record Data

Identifying predictors of early trial termination: a meta-epidemiological study utilising elements of the research ethics committee evaluation

Patient preference trials in oncology: a scoping review and recommendations on reporting

What is the research question? Estimands explained

Excess mortality during the first 2 years of the COVID-19 pandemic (2020-2021) in the Netherlands: Overall and across demographic subgroups

When selection becomes selection bias

Dependent observations in clinical research

Replication studies in the Netherlands: Lessons learned and recommendations for funders, publishers and editors, and universities

Directed acyclic graphs in clinical research

Real‐World Evidence to Inform Regulatory Decision Making: A Scoping Review

Ten things to remember about propensity scores

Operative versus non-operative treatment of ulnar styloid process base fractures: a systematic review and meta-analysis

Let’s Agree to Disagree on Operative Versus Nonoperative Treatment for Distal Radius Fractures in Older People: Protocol for a Prospective International Multicenter Cohort Study

Predicting nosocomial pneumonia risk in level-1 trauma patients: an external validation study using the Trauma Quality Improvement Program.

Comparison of likelihood penalization and variance decomposition approaches for clinical prediction models: A simulation study

Cardiovascular Risk Prediction in Men and Women Aged Under 50 Years Using Routine Care Data

Unintended impact of pharmacovigilance regulatory interventions: A systematic review

Dynamics in cardiac surgery: trends in population characteristics and the performance of the EuroSCORE II over time

Applicability of European Society of Cardiology guidelines according to gross national income

Assessing Heterogeneity of Treatment Effect in Real-World Data

Perspective; recommendations for improved patient participation in decision-making for geriatric patients in acute surgical settings

Mobile health for cardiovascular risk management after cardiac surgery: results of a sub-analysis of The Box 2.0 study

Subgroup analyses in clinical research: too tempting?

Intravesical aminoglycoside instillations as prophylaxis for recurrent urinary tract infection: patient satisfaction, long-term safety and efficacy

Evaluating Cluster-Based Synthetic Data Generation for Blood-Transfusion Analysis

Collaborators (30)

Satu J Siiskonen

Rik Peels

Maarten van Smeden

Jonna Brenninkmeijer

Margreet Kloppenburg

Cees van Nieuwkoop

Artuur Leeuwenberg

Matthijs van Leeuwen

Bryan van de Wall

Laura Nynke van der Laan

Marieke J.H. Wermer

Diederick E Grobbee

Maarten Derksen

Saskia Le Cessie

Hans Van Eyghen

Tomas Lasys

Reto Babst

Hein Putter

Tobias Bonten

Olaf M Dekkers

Fredrik Nyberg

kaori nomura

Surya Gayet

Helga Gardarsdottir

Mattijs E Numans

Kristina Laugesen

Barbara Casadei

Seye Abimbola

Stephanie Meirmans

Douwe Atsma

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