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Sven Hennig

University of Amsterdam

Netherlands

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Research Interests

Organic Chemistry

40%

Biochemistry

70%

Protein Chemistry

50%

Chemical Biology

40%

Ligand Design

30%

Organic Reactions

30%

Chemical Synthesis

30%

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Articles15

Helicity-Dependent Enzymatic Peptide Cyclization

Article Link

Year:

2025

Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography

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Year:

2025

Binding dynamics of a stapled peptide targeting the transcription factor NF-Y

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Year:

2024

Covalent bicyclization of protein complexes yields durable quaternary structures

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Year:

2024

Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene β-Catenin.

Article Link

Year:

2024

Environment-Responsive Peptide Dimers Bind and Stabilize Double-Stranded RNA

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Year:

2023

Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions

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Year:

2023

Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir

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Year:

2023

Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19

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Year:

2022

Enantioselective Total Synthesis of (−)-Limaspermidine and (−)-Kopsinine by a Nitroaryl Transfer Cascade Strategy

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Year:

2022

Enantioselective Total Synthesis of (−)‐Limaspermidine and (−)‐Kopsinine by a Nitroaryl Transfer Cascade Strategy

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Year:

2022

Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

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Year:

2021

MMP activation–associated aminopeptidase N reveals a bivalent 14-3-3 binding motif

Article Link

Year:

2020

Adapting free energy perturbation simulations for large macrocyclic ligands

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Year:

2020

Discovery of N-(4-Aminobutyl)-N′-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1)

Article Link

Year:

2020

Collaborators12

Anthony Green

David Phillips Research Fellow and Lecturer in Organic Chemistry/Chemical Biology

The University of Manchester

UNITED KINGDOM

Alan Gerber

Assistant Professor

Amsterdam UMC Locatie AMC Divisie 9

NETHERLANDS

Ioana-Mariuca Ilie

Academic, Assistant Professor, null

University of Amsterdam

NETHERLANDS

Saskia Neubacher

University of Amsterdam

NETHERLANDS

Anouk Rijs

University of Amsterdam

NETHERLANDS

Nicholas Pearce

University of Amsterdam

NETHERLANDS

Eelco Ruijter

University of Amsterdam

NETHERLANDS

Tom Grossmann

University of Amsterdam

NETHERLANDS

Tilman Hackeng

University of Maastricht

NETHERLANDS

Arjan Griffioen

Professor of Experimental Oncology and Angiogenesis

VU medisch centrum

NETHERLANDS

Alejandro Yeste Vázquez

University of Amsterdam

NETHERLANDS

Helena Danielson

Uppsala University

SWEDEN

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