Tania de Koning-Ward

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Professor of Molecular Microbiology

Deakin University

Australia

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About

Professor Tania de Koning-Ward is a faculty member in the Department of Molecular Microbiology at Deakin University, Australia. Her research focuses on antimalarial drug development, including the functional proof of essential proteins in malaria parasites and the optimization of various compounds targeting key mitochondrial and transport proteins. Professor de Koning-Ward has contributed to advancing the understanding of Plasmodium falciparum biology and therapeutic strategies through her recent publications.

Recent Grants

Grant: Close

Functional resolution of PTEX, the exporter of virulence factors in malaria parasites.

Open Date: 2017-01-01

Close Date: 2020-01-01

Grant: Close

The role of novel and essential bromodomain proteins in coordinating malaria parasite gene regulation and their potential as anti-malarial targets

Open Date: 2017-01-01

Close Date: 2019-01-01

Grant: Close

Why malaria parasites have a unique translocon

Open Date: 2016-01-01

Close Date: 2018-12-31

Grant: Close

Functional dissection of the malaria RhopH complex and its contribution to new permeation pathways

Open Date: 2015-01-01

Close Date: 2018-01-01

Grant: Close

Breaking malaria's lethal grip: Targeting the assembly of an adhesive complex on infected red blood cells

Open Date: 2015-01-01

Close Date: 2017-01-01

Articles (22)

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2025

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2020

Collaborators (22)

Georges Grau

Professor, Chair of Vascular Immunology

University of Sydney

AUSTRALIA

Tania de Koning-Ward

Research Interests

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About

Recent Grants

Articles (22)

Utilisation of an in vivo malaria model to provide functional proof for RhopH1/CLAG essentiality and conserved orthology with P. falciparum

Guanidinium Chloride-Induced Haemolysis Assay to Measure New Permeation Pathway Functionality in Rodent Malaria Plasmodium berghei

Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity

Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein

Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy

Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1.

Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.

Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.

Dissecting EXP2 sequence requirements for protein export in malaria parasites

Altered gastrointestinal tract structure and microbiome following cerebral malaria infection

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics

The <i>P. falciparum</i> alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries

Sequence elements within the PEXEL motif and its downstream region modulate PTEX-dependent protein export in Plasmodium falciparum.

<i>Cish</i> knockout mice exhibit similar outcomes to malaria infection despite altered hematopoietic responses.

Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

Editorial: Molecular Approaches to Malaria 2020.

Defining the Essential Exportome of the Malaria Parasite

Molecular approaches to Malaria 2020

Plasmodium translocon component EXP2 facilitates hepatocyte invasion

Collaborators (22)

Georges Grau

Sheena McGowan

Freya Fowkes

Danae Schulz

Brad Sleebs

Michael Duffy

Wai-Hong Tham

Anya E. Shindler

Mikha Gabriela

Darren J Creek

Adele Lehane

Justin Boddey

Vicky Avery

Vanessa Zuzarte Luís

Michaela Petter

Giel van Dooren

Ashley Franks

Peter J. Scammells

Jennifer Wood

Elisa L. Hill-Yardin

Alyssa Barry

Susan Charman

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