Brad Sleebs

Laboratory Head

Walter and Eliza Hall Institute of Medical Research

Australia

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About

Brad Sleebs is the Laboratory Head at the Walter and Eliza Hall Institute of Medical Research in Australia. His research focuses on the development of novel anthelmintics and antimalarials, utilizing innovative methodologies such as deep learning for candidate prioritization and high-throughput screening for compound effectiveness. Recent publications highlight advancements in targeting specific proteins in malaria and helminth infections, underscoring his contributions to identifying and optimizing therapeutic agents.

Articles (19)

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2025

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2023

Collaborators (11)

Peter Czabotar

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Tania de Koning-Ward

Professor of Molecular Microbiology

Deakin University

AUSTRALIA

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Marcus Lee

Wellcome Sanger Institute

UNITED KINGDOM

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Robin B. Gasser

Redmond Barry Distinguished Professor

University of Melbourne

AUSTRALIA

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Wai-Hong Tham

Laboratory Head

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Mikha Gabriela

University of Melbourne

AUSTRALIA

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Tao Wang

University of Melbourne

AUSTRALIA

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Adele Lehane

Australian National University

AUSTRALIA

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Vicky Avery

Distinguished Professor

Griffith University

AUSTRALIA

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Giel van Dooren

Senior Lecturer

Australian National University

AUSTRALIA

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Alyssa Barry

Professor

Deakin University

AUSTRALIA

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Brad Sleebs

Research Interests

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About

Articles (19)

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

Advances in Anthelmintic Target Identification

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.

Prediction and Prioritisation of Novel Anthelmintic Candidates from Public Databases Using Deep Learning and Available Bioactivity Data Sets

Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity

Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans

An adaptable, fit-for-purpose screening approach with high-throughput capability to determine speed of action and stage specificity of anti-malarial compounds

A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity.

BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents

Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism.

Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1.

Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.

Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics

Sequence elements within the PEXEL motif and its downstream region modulate PTEX-dependent protein export in Plasmodium falciparum.

Chemo‐proteomics in antimalarial target identification and engagement

A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in <i>Plasmodium falciparum</i> through Potential Inhibition of the Parasite's PI4KIIIB Enzyme.

Collaborators (11)

Peter Czabotar

Tania de Koning-Ward

Marcus Lee

Robin B. Gasser

Wai-Hong Tham

Mikha Gabriela

Tao Wang

Adele Lehane

Vicky Avery

Giel van Dooren

Alyssa Barry

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