Titia K Sixma

Netherlands

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Articles (15)

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2025

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2025

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2024

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2024

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2024

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2024

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

Collaborators (9)

Noam Zelcer

University of Amsterdam

NETHERLANDS

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Haico Van Attikum

Professor/Principal Investigator

Leiden University Medical Center

NETHERLANDS

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Meindert H. Lamers

Leiden University Medical Center

NETHERLANDS

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Peter Friedhoff

Adjunct Professor

GERMANY

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Malte Gersch

TU Dortmund

GERMANY

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Dea Slade

Universität Wien

AUSTRIA

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Friedrich Förster

Professor

Utrecht University

NETHERLANDS

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Hannes Lans

Associate Professor

Erasmus MC

NETHERLANDS

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Susan Kloet

Assistant Professor - Head, Leiden Genome Technology Center

Leiden University Medical Center

NETHERLANDS

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Titia K Sixma

Research Interests

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Articles (15)

Profiling BRCA1-BRCT interactions and their functional relevance at amino acid resolution

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA

MutL Activates UvrD by Interaction Between the MutL C-terminal Domain and the UvrD 2B Domain

The small CRL4<sup>CSA</sup> ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics.

STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment.

Variety in the USP deubiquitinase catalytic mechanism

Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding

Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF

Proteomic analysis identifies novel binding partners of BAP1.

AI revolutions in biology

Insert L1 is a central hub for allosteric regulation of USP1 activity

The selection process of licensing a DNA mismatch for repair

K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap

Structural analysis of the LDL receptor–interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site

Collaborators (9)

Noam Zelcer

Haico Van Attikum

Meindert H. Lamers

Peter Friedhoff

Malte Gersch

Dea Slade

Friedrich Förster

Hannes Lans

Susan Kloet

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