Caroline Paul

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Assistant Professor

Delft University of Technology

Netherlands

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About

Caroline Paul is an Assistant Professor at Delft University of Technology in the Netherlands. Her research encompasses enzymatic synthesis and biocatalysis, with a focus on monooxygenases, reductive amination, and asymmetric synthesis techniques. Recent publications include work on the synthesis of enantiopure compounds and innovative biocatalytic processes utilizing whole-cell systems.

Recent Grants

Grant: Close

Biocatalytic alkylation: fitting enzymes for selective C-C bond formations

Open Date: 2021-01-01

Close Date: 2025-12-31

Grant: Close

Light-driven sustainable biocatalysis training network

Open Date: 2018-01-01

Close Date: 2021-12-31

Grant: Close

Enhancing Nature's catalysts: new vitamins for enzymes

Open Date: 2016-01-15

Close Date: 2019-01-15

Grant: Close

Synthetic nicotinamide cofactors for new and improved biocatalytic processes

Open Date: 2013-05-01

Close Date: 2015-04-30

Grant: Close

A EUROPEAN BIOTECHNOLOGY TRAINING NETWORK FOR THE SUPPORT OF CHEMICAL MANUFACTURING

Open Date: 2009-07-01

Close Date: 2013-06-30

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2022

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2022

Collaborators (22)

Marc Nowaczyk

Professor

University of Rostock

GERMANY

Caroline Paul

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About

Recent Grants

Articles (20)

Discovery and Synthetic Applications of a NAD(P)H-Dependent Reductive Aminase from Rhodococcus erythropolis

Towards high atom economy in whole-cell redox biocatalysis: up-scaling light-driven cyanobacterial ene-reductions in a flat panel photobioreactor

Enzymatic Synthesis of Enantiopure (R)‐Citronellal from Geraniol via a Short‐Chain Dehydrogenase and Ene Reductase

Enantioselective synthesis of (R)-citronellal from geraniol with an immobilised copper alcohol oxidase and ene reductase

Harnessing a versatile monooxygenase GorA to synthesize N-hydroxy compounds

Asymmetric Enantio-complementary Synthesis of Thioethers via Ene-Reductase-Catalyzed C–C Bond Formation

H2-driven biocatalysis for flavin-dependent ene-reduction in a continuous closed-loop flow system utilizing H2 from water electrolysis

Asymmetric Monoreduction of α,β-Dicarbonyls to α-Hydroxy Carbonyls by Ene Reductases

Ene-Reductase-Catalyzed Oxidation Reactions

Insights into E. coli cyclopropane fatty acid synthase (CFAS) towards enantioselective carbene free biocatalytic cyclopropanation.

Exciting Enzymes: Current State and Future Perspective of Photobiocatalysis

Peroxygenase‐Catalysed Selective Oxidation of Silanes to Silanols

Peroxygenase‐Catalysed Selective Oxidation of Silanes to Silanols

Peroxygenase‐Promoted Enzymatic Cascades for the Valorisation of Fatty Acids

Enantio-Complementary Synthesis of 2-Substituted Pyrrolidines and Piperidines via Transaminase-Triggered Cyclizations

Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform

Exploring the Temperature Effect on Enantioselectivity of a Baeyer‐Villiger Biooxidation by the 2,5‐DKCMO Module: The SLM Approach

A Peroxygenase‐Alcohol Dehydrogenase Cascade Reaction to Transform Ethylbenzene Derivatives into Enantioenriched Phenylethanols

Synthesis of Chiral Amines via a Bi‐Enzymatic Cascade Using an Ene‐Reductase and Amine Dehydrogenase

Collaborators (22)

Marc Nowaczyk

Christian Michael Heckmann

Lars Lauterbach

Selin Kara

Mickael Lafond

Peter-Leon Hagedoorn

Willem van Berkel

Miguel Alcalde

Wolfgang Kroutil

Lucija Sovic

Jelena Spasic

Véronique Alphand

Paula Tamagnini

Frank Hollmann

Allison Elizabeth Wolder

Christoph K. Winkler

Sandy Schmidt

Robert Kourist

Sarah Barry

Ewald Jongkind

Rocio Villa

Jean-Marc G. Daran

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