PhD and Postdoctoral Positions in Co-Transcriptional Splicing Using Cryo-EM and Biochemistry MRC Laboratory of Molecular Biology in United Kingdom

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

PhD opportunity in DNA repair at stalled replication forks at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . The project focuses on DNA repair , replication stress , and the Fanconi Anaemia (FA) pathway , with particular attention to how cells respond to DNA crosslinks and stalled replication forks. The research aims to understand the molecular mechanisms of crosslink repair and the role of the FANCD2-FANCI heterodimer and FA core complex in mai...

PhD opportunity at the University of Dundee in molecular basis of transcriptional regulation during mammalian pre-implantation development . This project focuses on how pioneer transcription factors regulate trophectoderm lineage commitment during early mammalian development, with emphasis on chromatin biology , nucleosome interactions , and developmental biology . The work combines biochemistry , structural biology , cryo-EM , and cell culture to uncover how transcription factors engage nucleos...

PhD opportunity in Structural Biology , Molecular Biology , Biochemistry , and Human Genetics focused on the human replisome and the mechanisms of DNA replication. The project is hosted by the Medical Research Council (Cambridge) Laboratory of Molecular Biology in the United Kingdom and is supervised by Dr J Yeeles . The lab studies how the human replication machinery is assembled, how it functions during normal DNA duplication, and how it responds to obstacles such as DNA damage and protein bar...

PhD project in the molecular architecture of neurotransmission at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . The project investigates chemical synapses , neurotransmitter receptors , and large synaptic protein assemblies that connect pre-synaptic release sites with post-synaptic receptors. The research is centered on the structural and functional analysis of receptor supra-molecular complexes, with emphasis on the GABAA and glutamate ligand-...