PhD in Co-translational Protein Folding on the Ribosome Using smFRET and Molecular Dynamics Medical Research Council (Cambridge) Laboratory of Molecular Biology in United Kingdom

PhD opportunity in pathological protein assembly in neurodegenerative diseases at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom . The project is centered on the molecular pathology of neurodegeneration, with a focus on amyloid filament formation by disease-associated proteins such as TDP-43 , annexin A11 , and TAF15 . Two PhD project directions are described. One aims to reproduce pathological protein filament structures in vitro using protein biochemist...

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

PhD opportunity at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom on mTORC2 activation , AKT signaling , and related biochemistry , cancer biology , and molecular biology questions. The project focuses on how mTORC2 integrates activating inputs to control anabolism, survival, and cytoskeletal remodelling, with emphasis on positive feedback loops and upstream activation mechanisms. The student will help elucidate natural mechanisms of mTORC2 activation a...

PhD opportunity: Hidden RAS conformations at the membrane at the Medical Research Council (Cambridge), Laboratory of Molecular Biology. This project focuses on RAS proteins , key molecular switches in human signalling and major drivers of cancer when mutated. The research asks how the plasma membrane shapes RAS structure, dynamics, and signalling, with an emphasis on detecting transient, low-population conformations that are difficult to capture by conventional structure determination. The stude...

PhD opportunity in Protein Aggregates and Neurodegeneration at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with Dr H McMahon. This project explores how protein aggregates accumulate, become toxic to brain cells, and spread in neurodegenerative disease. Two related PhD projects are available in the McMahon group. One focuses on aggregate uptake mechanisms , including Aggregation-Dependent Endocytosis, receptor identification, aggregate size effects, and ways to prev...