PhD in Endoplasmic Reticulum Transport and Morphoregulation in Neuron (Patho) Physiology University of Cambridge in United Kingdom

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on programmed axon death , SARM1 , NMNAT2 , and protein design . The project focuses on understanding the mechanism of programmed axon death, an intrinsic axonal death pathway implicated in neurodegenerative disease and injury. The work will use rational protein design to create variant forms of SARM1 or hybrid reporter constructs to study activation, stability, enzyme activity, and post-translational modi...

PhD opportunity at the University of Cambridge in preclinical human neural organoid and computational/AI model development . This project sits at the intersection of neuroscience , neural organoids , single-cell transcriptomics , spatial transcriptomics , and computational AI . The aim is to combine patient-specific iPSC-derived human neural organoids with postmortem CNS samples to build large-scale AI frameworks that can identify disease-associated cellular states, molecular biomarkers, and pot...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on Mitochondrial Genetic Determinants of Multiple Sclerosis . This project investigates how mitochondrial genetic variants influence the outcome of multiple sclerosis (MS) . The research builds on prior genome-wide association studies (GWAS) that have identified more than 200 autosomal variants associated with MS, while extending the analysis to the mitochondrial genome. Using a dedicated mitochondrial var...

PhD opportunity at the University of St Andrews in the School of Psychology and Neuroscience on descending and ascending control of locomotor and respiratory central pattern generators (CPGs) in health and disease . This project sits at the intersection of neuroscience , neurology , cell biology , and molecular biology , with a strong focus on motor control, respiratory control, and disease-relevant circuit mechanisms. The research will investigate how supraspinal descending pathways and ascendi...

PhD opportunity: Transcellular Propagation of Tauopathies at the University of Cambridge, Department of Clinical Neurosciences. This project investigates how fibrillar tau aggregates spread between brain cells in neurodegenerative disease, with a focus on disease-specific tau folds and their selective accumulation in different CNS cell types. The research is especially relevant to neuroscience , neurology , biological sciences , and medical science . Research themes and methods: tau cytosolic en...