PhD in Endoplasmic Reticulum Transport and Morphoregulation in Neuron (Patho) Physiology University of Cambridge in United Kingdom

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on programmed axon death , SARM1 , NMNAT2 , and protein design . The project focuses on understanding the mechanism of programmed axon death, an intrinsic axonal death pathway implicated in neurodegenerative disease and injury. The work will use rational protein design to create variant forms of SARM1 or hybrid reporter constructs to study activation, stability, enzyme activity, and post-translational modi...

PhD opportunity at the University of Cambridge in preclinical human neural organoid and computational/AI model development . This project sits at the intersection of neuroscience , neural organoids , single-cell transcriptomics , spatial transcriptomics , and computational AI . The aim is to combine patient-specific iPSC-derived human neural organoids with postmortem CNS samples to build large-scale AI frameworks that can identify disease-associated cellular states, molecular biomarkers, and pot...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on Mitochondrial Genetic Determinants of Multiple Sclerosis . This project investigates how mitochondrial genetic variants influence the outcome of multiple sclerosis (MS) . The research builds on prior genome-wide association studies (GWAS) that have identified more than 200 autosomal variants associated with MS, while extending the analysis to the mitochondrial genome. Using a dedicated mitochondrial var...

PhD opportunity in astrocyte biology and molecular neuroscience at Cardiff University This funded PhD project, titled Silent Architects: Uncovering How Astrocytes Shape Brain Health , is based at Cardiff University, Cardiff School of Medicine, in the United Kingdom. The project investigates how astrocytes regulate brain function, including neuronal activity, metabolism, extracellular matrix organisation, and resilience to disease. The research will focus on novel astrocyte-enriched genes and sig...

Cardiff University is advertising a funded PhD project on unravelling the physiological drivers of sleep-dependent glymphatic flow in Alzheimer’s disease using advanced MRI . The project sits in the Cardiff School of Physics and Astronomy and is supervised by Prof Kevin Murphy . The research is part of the SleepBoost study, a £4.3m multi-centre investigation into how improving slow-wave sleep may enhance waste clearance in the brain and potentially slow or reverse Alzheimer’s disease pathology. ...