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KU Leuven
Top university
4 days ago
Postdoctoral Researcher in Dolichol Metabolism, Lipid Biology and Congenital Disorders of Glycosylation KU Leuven in Belgium
Degree Level
Postdoc
Field of study
Cell Biology
Funding
This is a full-time, funded postdoctoral position for one year, with the possibility of extension for at least one additional year after positive evaluation. Remuneration follows the KU Leuven salary scale and includes travel reimbursement.
Deadline
Nov 30, 2026
Country
Belgium
University
KU Leuven
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About this position
KU Leuven is seeking a postdoctoral researcher to join the laboratory of Professor Matthew Wilson within the GPURE subsection of the Department of Development and Regeneration. The laboratory studies human metabolism and rare inherited metabolic disorders, with a particular focus on congenital disorders of glycosylation (CDG), a group of more than 200 disorders associated with diverse clinical features including intellectual disability, skeletal abnormalities and epilepsy.
The project is supported by the European Research Council Starting Grant DOLIGOAL and investigates the biology of dolichol, a lipid that underlies many eukaryotic glycosylation pathways. Following the identification of a new CDG and revision of the dolichol synthesis pathway, the project will address missing steps in dolichol metabolism, its transport and storage, and the broader importance of these processes for human health and disease. The research has relevance to rare inherited metabolic disorders as well as conditions such as neurodegeneration and hypercholesterolaemia.
The researcher will work across molecular biology, cell biology and biochemistry. Activities include DNA, RNA and protein manipulation; work with bacterial and mammalian cell lines; generation of cellular models using CRISPR/Cas9 gene editing; lentiviral transduction using L2+ cell culture; enzymological analysis of lipid metabolic pathways; and LC-MS-based lipid or metabolomics analysis in collaboration with Professor Bart Ghesquière’s laboratory at VIB-KU Leuven.
The successful candidate will contribute intellectually to the laboratory, develop original research ideas, present findings at weekly meetings and international conferences, and supervise bachelor’s, master’s and PhD students. The team comprises approximately 6–8 researchers and operates within an international collaborative environment, including the ERDERA RADICAL-CDG network. The position is based on KU Leuven’s health sciences campus in Leuven, with access to state-of-the-art research infrastructure and supplementary professional training.
Funding details
This is a full-time, funded postdoctoral position for one year, with the possibility of extension for at least one additional year after positive evaluation. Remuneration follows the KU Leuven salary scale and includes travel reimbursement.
What's required
Applicants must have obtained or be about to obtain a PhD in Biomedical Sciences, Medicine, Biochemistry, Bioengineering or a related field. They should have an excellent publication and dissemination record, strong motivation to formulate and pursue original scientific ideas, and a creative, dynamic and analytical mindset. Excellent spoken and written English at least at C1 level is required. Prior training in standard molecular biology techniques and cell culture is required, as is strong experience in biochemistry, enzymology and mass spectrometry, ideally involving lipid metabolism. Candidates must be able to work independently and collaboratively and communicate effectively.
How to apply
Apply through the KU Leuven online application tool using the “Apply for Position” button. Submit a cover letter, CV, BSc/MSc/PhD diploma and transcripts, contact details for at least two referees including your PhD supervisor, and any additional relevant information such as a publication list.
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